Research results discussed below debunk some misconceptions about nonantibiotic
systemic agents that may limit their use.
This guideline by the International Society of Travel Medicine provides clinically relevant, useful, and practical guidance to providers regarding the use of antibiotic and nonantibiotic
therapies for the prevention and treatment of TD.
Over the last decade, interest in FMT as an effective nonantibiotic
means to treat recurrent Clostridium difficile infections has surged.
"This study could also serve as a model for introduction of other nonantibiotic
topical therapies for use in other bacterial infections of the eye," Dr Ebenezer added.
Combinations of antibiotics and nonantibiotic
drugs enhance antimicrobial efficacy.
Hamon et al., "Nonantibiotic
macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases," American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.
treatment alternatives may be required.
Clavulanic acid is a nonantibiotic
compound that can inhibit the beta-lactamase enzyme, thereby prolonging the antibacterial activity of amoxicillin .
Prophylactic use of nonantibiotic
antimicrobials is common for catheter users as well as community UTI sufferers.
Interestingly, treatment with immunosuppressants such as corticosteroids or nonantibiotic
macrolides and alternative therapies such as plant extracts and polyphenols have shown a relevant reduction in these inflammation-based biomarkers [133-135].
A safe, nonantibiotic
answer to a major problem facing aquaculture and seafood safety could be very welcome.
Another interim solution being explored is the use of antibiotic resistance breakers (ARB) which involves co-administering a nonantibiotic
drug with a failing antibiotic.