Whether this reaction is dependent on the nonantigenic
or antigenic components of the vaccine has yet to be determined.
It is nonantigenic
because it is autologous, and there have been no detected adverse effects (29).
The epitopes [sup.13][IAYGHPLSTSQI.sup.24], [sup.110][PRMYTCRAACDI.sup.121], [sup.432][SSGFEYEVFLKDMH.sup.445], [sup.519][DLLSKNLITEYDKKYFEPDT VNDQFNKIEFAQD.sup.551], [sup.619][DFNNEIETYYKANAAAYRSDFYTI.sup.642], [sup.706][TRSAQHSIMTN.sup.716], [sup.848][CGDKYYYSDGKEHAKDGS.sup.865], and [sup.1089][CITLPHETYCNDMDILEPII.sup.1108] are nonantigenic
among the 19 epitopes due to their low antigenicity score in the VaxiJen server (Table 4).
In addition, the PGA scaffold can be used as a nonantigenic
implant, which would not have a rejection reaction once implanted.
In general, an ideal hemostatic agent should be highly efficacious, easy to use and sterilize, nonantigenic
, stable, and inexpensive .
These microbial polyesters are attracting more and more attention in tissue engineering because they are biodegradable, nonantigenic
, and biocompatible.
A relationship to skin distension has been proposed due to the higher prevalence of PUPPP in multiple gestations and in women with increased weight gain during pregnancy, or the condition may represent a cutaneous response to the presence of circulating fetal cells that have invaded maternal skin.31,32Another theory has been proposed that stretching of the skin damages the connective tissue causing subsequent conversion of nonantigenic
molecules to antigenic ones, leading to skin eruption.33,34
To effectively clean and disinfect the root canal system, an irrigant should be able to disinfect and penetrate dentin and its tubules, offer long-term antibacterial effect (substantivity), remove the smear layer, and be nonantigenic
, nontoxic, and noncarcinogenic.
Although fractions 30 to 36 were contaminated with other nonantigenic
polypeptide bands, the only cross-reacting antigen contained in these fractions was the 53 kDa polypeptide band.
Ideal scaffolds for cartilage tissue engineering should be satisfied with the following basic requirements: biocompatible, biodegradable, highly porous, suitable for cell attachment, proliferation and differentiation, osteoconductive, noncytotoxic, flexible and elastic, and nonantigenic
Gabexate mesylate (FOY) and nafamostat mesilate (6-amidino-2naphthyl p-guanidinobenzoate dimethane sulfonate; FUT) are nonantigenic
synthetic serine protease inhibitors that have been used to treat pancreatitis and DIC and as anticoagulants for extracorporeal circulation with hemodialysis [10, 11].
In the cationic polymer, poly(L-lysine) (PLL) is a well-known nonviral gene carrier that is biodegradable and nonantigenic
. Nevertheless, it is toxic and tends to bind nonspecifically to the surface of all mammalian cells .