Background: Hyperglycemia on admission has been found to elevate risk for mortality and adverse clinical events after acute myocardial infarction (AMI), but there are evidences that the relationship of blood glucose and mortality may differ between diabetic and nondiabetic
A meta-analysis was conducted on 11 randomized controlled trials (including a total of 26,340 nondiabetic
participants) that examined the effect of niacin therapy (1-4 g per day) on the incidence of diabetes.
The prevalence of diabetes mellitus (types 1 and 2 combined) was estimated, and the nondiabetic
and diabetic groups were compared.
Keshawarz, a doctoral student and research assistant at the University of Colorado Barbara Davis Center for Childhood Diabetes, Aurora, and her associates used carotid intima-media thickness (cIMT) and the presence of coronary artery calcification to measure the cardiovascular risk by menopausal status in 106 women with type 1 diabetes and 140 nondiabetic
women who were enrolled in CACTI.
The data combined for the analysis were derived from three controlled studies: PIVENS (Pioglitazone Versus Vitamin E Versus Placebo for the Treatment of Nondiabetic
Patients With Nonalcoholic Steatohepatitis], TONIC (Treatment of Nonalcoholic Fatty Liver Disease in Children), and FLINT (Farnesoid X Receptor Ligand Obeticholic Acid in NASH Treatment Trial).
The study included 78,241 diabetics treated with metformin and 12,222 prescribed sulfonylureas, matched with 90,463 nondiabetic
The results, from more than 3,700 overweight and obese nondiabetic
adults, were presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
She presented an analysis of a large Manitoba province-wide database that included 3,518 patients with type 1 or type 2 diabetes and 36,085 nondiabetic
controls, all at least 50 years old when they underwent bone mineral density testing during 1987-2008.
Adults with type 1 diabetes are known to have a higher risk of cardiovascular disease compared with nondiabetic
adults, said Ms.
Diabetic patients have a higher risk of atherosclerotic cardiovascular disease than nondiabetic
Investigators in a collaborative meta-analysis looked through information from 13 trials in which 90,000 stable, nondiabetic
patients received statins or a placebo at random.
Veterans not meeting these criteria were defined as nondiabetic