However, an intravascular contrast injection (nondiffusible
), while unable to absolutely quantify CBF, can infer it by using the central volume principle [12,13] (cerebral blood flow calculated as a ratio between blood volume in a given volume of tissue and the average time for the tracer to pass through this volume).
 Progesterone with its half-life of 30 min causes proportionate fluctuations of diffusible ionic calcium to its nondiffusible
protein bound form, as an immediate effect.
Since then, numerous imaging techniques have been developed and applied to evaluate brain function , using different tracers (diffusible or nondiffusible
, endogenous or exogenous), with different technical requirements.
Over the last decades, a vast repertoire of cryoprotectants has been discovered that could be classified into two main categories, namely, diffusible (intracellular agents) and nondiffusible
The colonies grown were around 2 to 3 mm in diameter, convex, nonlactose fermenting, round, glistening, and smooth and produced violet nondiffusible
pigment (Figure 1).
Haptotaxis is defined as a directed migratory response of cells to gradient of fixed nondiffusible
It produces a nondiffusible
red pigment called prodigiosin.
9: Drug susceptibility test on Mueller-Hinton agar with Disk diffusion method also shows nondiffusible
red pigmentation and the following sensitivity pattern:
All of them produced nondiffusible
brown pigments in agar medium, showed motile cells, formed cysts in butanol-containing medium, and showed no fluorescent pigments under UV light (data not shown).
This results in a decrease in blood volume and, hence, an increase in the concentration of anything left behind, i.e., large protein-bound nondiffusible
analytes and cells.