In vivo gene delivery and stable transduction of nondividing
cells by a lentiviral vector.
Immunotoxins exert the function of cell killing by inhibiting protein synthesis, which is toxic to both dividing and nondividing
As a result, the karyotype in some cases may be noninformative when the neoplastic cells are scant or nondividing
Most importantly, however, Cpf1 generates staggered cuts (as opposed to blunt ends by Cas9), which make it an attractive endonuclease for achieving true gene edits in nondividing
cells in which the cell-autonomous homology-directed repair mechanism is not working effectively.
Somatic mutations of mtDNA are potentially more harmful for cell physiology compared to somatic damage of nDNA; consequently, the DNA repair systems may play a more important role in the mitochondria than in the nuclei, especially in nondividing
22) Neuroepigenetics is a new subfield focusing on epigenomic research of nondividing
, or slowly dividing, cells.
It turned out that in the nondividing
cells, HIF-1a was binding to a protein that loads the DNA replication complex onto DNA strands, and preventing the complex from being activated.
Chronological lifespan is defined as the ability of stationary phase cultures to maintain viability over time in a nondividing
And array-based comparative genomic hybridization, which yields information on the chromosome count as well as micro-duplications and deletions, can be performed on nondividing
Our theory is that these remaining bacteria are in a metabolically dormant, nondividing
state," Barthold concludes.
Such a free exchange of mitochondrial DNA among nondividing
cells could challenge current understanding of cells as separate functional units, Eugenin says.
75) Still, I do not advocate seeing the papacy as a nondividing
local tradition, as Afanassieff did.