Neurocutaneous melanosis (NCM) is a rare congenital nonfamilial
nonheritable neurocutaneous syndrome with equal gender preponderance.
Given the low-quality evidence supporting most of these recommendations, the guideline calls for welldesigned observational studies to better quantify the risk of colorectal cancer among individuals with a family history of
nonheritable disease.
In our case, inclusion of the average family exposure can be interpreted similarly and may reflect both heritable and
nonheritable influences of the air pollution-ASD relationship, including that of the maternal genome on perinatal exposure or population genetic influences that regulate exposure response to air pollution.
[6], heritable genetic effects and
nonheritable environmental effects contribute to variability found in germplasm.
Because persister phenotypic tolerance is unlike resistance which is genetically determined, persister characteristics were considered to be
nonheritable by future progeny [91].
Epigenetic: Heritable or
nonheritable changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence; epigenetic changes can alter the appearance and structure of the DNA or the histone proteins around which the DNA is wound (e.g., DNA methylation, histone acetylation), thereby influencing gene expression.
Plasma lipid concentrations are representative quantitative traits; that is, they are controlled by multiple genes under the influence of
nonheritable environmental effects.
Rosner, "
Nonheritable cellular variability accelerates the evolutionary processes of cancer," PLoS Biology, vol.
Both long- and short-acting stimuli lead to epigenetic effects that result in 13 being long-term (heritable) or short-term (
nonheritable), respectively.
In the study, 58 percent of the variation measured in immune system responses was almost completely determined by
nonheritable factors, such as exposure to microbes.
Examining differences in the levels and activity states of these components within pairs of monozygotic and dizygotic twins, the Stanford scientists found that in three-quarters of the measurements,
nonheritable influences -- such as previous microbial or toxic exposures, vaccinations, diet and dental hygiene -- trumped heritable ones when it came to accounting for differences within a pair of twins.
Long- (heritable) or short-acting (
nonheritable) environmental cues can lead to long- or short-term epigenetic effects, respectively.