nonhistone

nonhistone

(ˌnɒnˈhɪstəʊn)
adj
relating to any of the eukaryotic proteins forming DNA complexes that are not histones
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
NCL is a nucleolar phosphoprotein that is also among the most abundant nonhistone proteins in the nucleus.
HMGB1 is the most abundant and prominent member of the HMG family of ubiquitous and highly conserved nonhistone chromosomal proteins found in higher eukaryotes [106].
[6] showed that MT1-MMP expression associates to an increased HMGA2 expression (a nonhistone DNA-binding nuclear protein involved in chromatin remodelling and gene transcription) in human PDAC tumours, suggesting that the marked fibrotic reaction may contribute to gemcitabine resistance through increased MT1-MMP-HMGA2 signalling.
All these posttranslational modifications of histones, as well as nonhistone proteins, regulate gene expression profiles through their effect on chromatin structure/remodelling.
High-mobility nuclear protein (HMGB) is a nuclear, nonhistone DNA-binding protein belonging to the HMGB family that consists of 3 nuclear proteins (HMGB1, HMGB2, and HMGB3).
In orbital fibroblasts, fibrates also upregulate mRNA and protein expression of the nonhistone chromosomal high-mobility group AT-hook 2, leptin, and functional TSH receptor inducing preadipocyte differentiation [137].
HMGB1 was identified as a nonhistone chromatin-binding protein about 30 years ago [9-11].
Because HDACs could not only regulate histones but also nonhistone proteins with multiple lysine residues acetylation, the gene expression or protein transcription could be upregulated or downregulated [31].
High mobility group box (HMGB)-1, one of the most well-known DAMP members, is a nonhistone protein with dual functions: intercellular transcriptional regulation by loose binding to chromatin and extracellular high potency signaling of inflammation to attract and activate various immunocompetent cells including monocytes and myeloid cells [39].
much more complex than other nonhistone localities because they must