Natura's facilities will be dedicated for the manufacture of coconut-oil fractions, coconut-based surfactants, and downstream packaging for consumer products which are sustainable, naturally derived, mild and nonirritant
. Product applications extend to health care, personal care, home care, as well as baby care.
Based on the observations made during the 48 h Patch Testing, the phytoene- and phytofluene-rich extracts tested may be classified as nonirritant
and having very good skin compatibility.
Although Surgicel is a relatively nonirritant
substance and is completely absorbed by the body in most instances, it is a foreign body and should be used as rarely as possible.
Natura's facilities will be used to manufacture coconut oil fractions, coconut-based surfactants, and downstream consumer products which are 'sustainable, naturally derived, mild and nonirritant
First alternative method validated by a retrospective weight-of-evidence approach to replace the draize eye test for the identification of nonirritant
substances for a defined applicability domain.
Although potential benefits and risks of combining irritant pyrethroids with nonirritant
insecticides from complementary classes remain to be satisfactorily assessed, our results suggest that WSEBs might be a potentially scalable delivery format with which to test these hypotheses empirically through large-scale field studies.
The skin irritation activity and wound healing results of the formulated nanoemulsion indicated the nonirritant
nature of the formulation and higher wound contraction rate when compared to the free drug counterpart .
Additionally, EGCG-loaded formulations were found to be tolerable and nonirritant
. These results highlight the potential of the produced drug delivery vehicles for ocular delivery of EGCG.
Thus, these data suggest that 20E may be non-genotoxic, non-reproductive-system toxic, non-cardiotoxic and nonirritant
. The software also predicted that 20E does not present hazardous fragments, which are interconnected with mutagenic effects.
It is nonirritant
, noninflammable, and produces bronchodilatation.
The assay allows classification into a nonirritant
, indeterminate and irritant.