Acetazolamide was the first nonmercurial
diuretic to be used in the clinic and played a key role in the development of the current drugs .
(5) This safety concern, plus the required attention to detail and the time involved in obtaining BP with auscultatory methods, has resulted in an increased use of electronic units and development of alternative nonmercurial
Because mercury compounds are readily absorbed through intact skin, FDA regulations restrict the use of these compounds as cosmetic ingredients: specifically, mercury compounds can be used only as preservatives in eye-area cosmetics at concentrations not exceeding 65 ppm (0.0065%) of mercury; no effective and safe nonmercurial
substitute preservative is available for use in such cosmetics.(*)