NNRTI

(redirected from nonnucleoside reverse transcriptase inhibitors)
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Related to nonnucleoside reverse transcriptase inhibitors: nucleotide reverse transcriptase inhibitors, Protease inhibitors

NNRTI

abbr.
non-nucleoside reverse transcriptase inhibitor
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.NNRTI - an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs
delavirdine, Rescriptor - a non-nucleoside reverse transcriptase inhibitor (trade name Rescriptor) used to treat AIDS and HIV
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
nevirapine, Viramune - a non-nucleoside reverse transcriptase inhibitor (trade name Viramune) used to treat AIDS and HIV
reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
Translations

NNRTI

abbr non-nucleoside reverse transcriptase inhibitor. V. inhibitor.
References in periodicals archive ?
The pooled, open-label study reported on 1,028 individuals who met a base criteria of stable viral suppression (viral load fewer than 50 copies/mL) by a first or second CAR regimen consisting of two nucleoside reverse transcriptase inhibitors (NR-TIs) plus a third drug (nonnucleoside reverse transcriptase inhibitors, integrase strand transfer inhibitors, or a protease inhibitor) for a minimum of 6 months at time of screening.
Zidovudine, protease inhibitors, and nonnucleoside reverse transcriptase inhibitors increase risk for dyslipidemia.
Lack of hepatotoxicity associated with nonnucleoside reverse transcriptase inhibitors. J Acquir Immune Defic Syndr, 2002, 29, 340-345.
This was primarily accounted for by mutations conferring resistance to the nonnucleoside reverse transcriptase inhibitors (J.
Updated guidelines for the use of rifamycins for the treatment of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors. MMWR 2004;53:37.
A single dose of tenofovir and emtricitabine at delivery reduced resistance to nonnucleoside reverse transcriptase inhibitors at 6 weeks after delivery by half.
But everything changed in the mid 1990s with the advent of two new classes of anti-HIV drugs--first in December 1995 with protease inhibitors, then in June 1996 with nonnucleoside reverse transcriptase inhibitors. Researchers found that combining these new drugs with older ones in a drug cocktail improved people's health, decreased side effects, lessened the likelihood of drug resistance, and brought HIV viral loads down to undetectable levels.
Truvada is indicated in combination with other antiretroviral agents (such as nonnucleoside reverse transcriptase inhibitors or protease inhibitors) in treating H1V-1 in among adults.
Existing studies of gender-based differences among persons with HIV disease have been conducted before the diffusion of protease inhibitors and nonnucleoside reverse transcriptase inhibitors or immediately thereafter.