sweeteners such as aspartame (Equal) and sucralose (Splenda) eroded market share.
Emerging data indicate that artificial, or nonnutritive
, sweeteners may have negative effects on metabolism, gut bacteria and appetite, although the evidence is conflicting.
An individual's craving, mouthing, or consumption of materials that are fundamentally nonnutritive
is described as pica.
Moreover, claims for 1) improved or increased production and performance, 2) alteration or improvement in function, or 3) treatment or prevention of disease are also considered drug claims, regardless of whether the ingredient is nutritive or nonnutritive
The nonpharmacologic strategies shown to be effective for reducing pain during short-term mild or moderately painful procedures include facilitated tucking, sensorial stimulation, nonnutritive
sucking, and breastfeeding or providing expressed human milk.
Furthermore, pacifiers can be used to stimulate nonnutritive
sucking in preterm newborns (PNs) with or without musical sounds (Poore et al.
sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms.
Nutritive and nonnutritive
sucking habits: A review.
Similarly another study which assessed the possible effects of five nonnutritive
sweeteners on cell proliferation morphology and cells' DNA by utilizing Caco2 HT-29 (colon) and HEK-293 (renal) cell lines.
Effects of nonnutritive
sucking on behavioral organization and feeding performance in preterm infants.
Duration of nutritive and nonnutritive
sucking behaviors and their effects on the dental archers in the primary dentition.
2 summarises the introduction of nonnutritive