reported in Caucasian population that FUT2 nonsecretor
status is associated with Crohn's disease .
Agglutination of indicator cells by antibody in tubes containing saliva indicates that the saliva does not contain the corresponding antigen (nonsecretor
Approximately 20% of the white population is homozygous for a recessive point mutation of the FUT2 gene, which leads to the absence of A, B, and H antigen expression, also called the nonsecretor
At his original trial, an expert testified that Vinson was a "nonsecretor
," which meant his blood type would not have shown up in the stain even if Vinson was the perpetrator, explaining the lack of his blood in the stain.
(46) In humans, it was recently suggested that a nonsecretor
genotype (i.e., a mutation in the FUT2 gene) is closely associated with susceptibility to IBDs such as Crohn's disease (47) or viral infection.
Recently, the Lewis gene (FUT3) and the secretor gene (FUT2) were cloned (2, 3), and several silent alleles that cause the Lewis-negative (4-9) and the nonsecretor
(1015) phenotypes, respectively, were identified.
Persons with a nonsecretor
gene (FUT2-/-) represent as much as 20% of the European population.
On the basis of a comparison of Ca 19-9 in nonsecretor
and secretor patients, ignoring non-significant differences in tumor stage and grade between the two groups, an examination of Ca 19-9 ratios showed a considerably higher concentration (P <0.01) in urine from nonsecretors
Splenocytes were fused with a nonsecretor
cell line sp2/0 and plated into Dulbecco's modified Eagle's medium containing hypoxanthine, aminopterin, and thymidine with 150 mL/L fetal bovine serum.
Moreover, a non-sense mutation in the fucosyltransferase gene 2 (FUT2), which gives rise to the nonsecretor
phenotype, has been found to provide almost complete protection from experimental and natural NoV infection (2,3).
None of the strains recognized nonsecretor
saliva, which showed that binding to human saliva required A, B, or H motifs.
Seven (8%) secretor and 3 (4%) nonsecretor
persons were Lewis negative and hence lacked Lewis antigen in saliva.