noscapine


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nos·ca·pine

 (nŏs′kə-pēn′)
n.
A nonnarcotic alkaloid obtained from the opium poppy, C22H23NO7, that has antitussive and antitumor properties and has been used as a cough suppressant.

[Alteration (influenced by Latin nōscere, to get to know; see notion) of gnoscopine, a racemic mixture of noscapine and its enantiomer : Greek (gi)gnōskō, first person singular of gignōskein, to know (from the fact that it was previously unknown); see gnō- in Indo-European roots + op(ium) + -ine.]
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References in periodicals archive ?
Genotoxic evaluation of morphine, buprenorphine, pentazocine and noscapine by micronucleus and comet assay in albino mice.
([paragraph]) Substances coded as prescription opioids were oxycodone, oxymorphone, hydrocodone, hydromorphone, tramadol, buprenorphine, methadone, meperidine, tapentadol, dextrorphan, levorphanol, propoxyphene, noscapine, pentazocine, and phenacetin.
Katyal et al., "Wheat germ agglutinin anchored chitosan microspheres of reduced brominated derivative of noscapine ameliorated acute inflammation in experimental colitis," Colloids and Surfaces B: Biointerfaces, vol.
Katyal, "Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells," Nanomedicine: Nanotechnology, Biology and Medicine, vol.
evaluated the use of columns packed with sub-2 [micro]m particles in SFC and UHPSFC conditions and provided systematic comparisons of the performance for pharmaceutical compounds such as steroids, benzodiazepines and their derivatives, butylparaben, mefenamic acid, diclofenac, acetaminophen, chlorthalidone, indapamide, papaverine, and noscapine at constant temperature and pressure using methanol as organic modifier [30].
No Alkaloid Name Commercial brand (s) Codeine Antitus[TM], Codicaps[TM], Tussipax[TM] Lobeline Citotal[TM], Lobatox[TM], Refrane[TM], Stopsmoke[TM] Noscapine Bequitusin[TM], Degoran[TM], Tossamine[TM], Tussisedal[TM] Theophylline Adenovasin[TM], Aerobin[TM], Euphyllin[TM], Theochron[TM] Ephedrine Amidoyna[TM], Bronchicum[TM], Peripherin[TM], Solamin[TM]
Abstract: In the present study, in vitro enzyme inhibitory studies on cinchonidine (1), cinchonine (2), quinine (3), noscapine (narcotine, 4) and santonine (5) were carried out.
Noscapine hydrochloride disrupts the mitotic spindle in mammalian cells and induces aneuploidy as well as polyploidy in cultured human lymphocytes.
In the other parts of the world, the main ingredient of crack is cocaine, but in Iran it is heroin which may also contain morphine, caffeine, codeine, noscapine, papaverine, dextromethorphan, and acetyl codeine or corticosteroids in varying amounts.
Recently, anticancer activity of noscapine, an opioid alkaloid in combination with cisplatin in human nonsmall cell lung cancer, in vitro and in vivo, in murine xenograft model was reported [74].