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An antibiotic, C31H36N2O11, produced by the actinomycete Streptomyces nivens, used primarily in research and to treat infections by gram-positive bacteria in certain animals.

[Probably Latin novus, new; see novice + (anti)bio(tic) + -in.]


(Pharmacology) pharmacol an aminocoumarin antibiotic, C31H36N2O11, derived from Streptomyces niveus, which works by inhibiting DNA synthesis in bacteria
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Noun1.novobiocin - an antibiotic obtained from an actinomycete and used to treat infections by Gram-positive bacteria
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
References in periodicals archive ?
Oka, "LC-MS/MS and centrifugal ultrafiltration method for the determination of novobiocin in chicken, fish tissues, milk and human serum," Journal of Chromatography B, vol.
It is part of the routine of the laboratory to test the drugs most used by veterinarians, in this way the 17 active ingredients used in this sensitivity tests were: PMN = novobiocin (40 [micro]g)+penicillin G procaine (40 [micro]g); CEQ = cefquinome (30 [micro]g); AMO = amoxicillin (10 [micro]g); DUL = danofloxacin (5 [micro]g); CTF = ceftiofur (30 [micro]g); CL = cephalexin (30 [micro]g); CN = gentamicin (10 [micro]g); TE = tetracycline (30 [micro]g); AM = ampicillin (10 [micro]g); ENO = enrofloxacin (5 [micro]g); NEO = neomycin (30 [micro]g); SUT = sulfatrim (25 [micro]g); AMC = ampicillin+colistin (30 [micro]g); CNM = cefalonium (30 [micro]g); ACA = amoxicillin (20 [micro]g) +clavulanic acid (10 [micro]g); OXA = oxacillin (1 [micro]g); and CIP = ciprofloxacin (5 [micro]g).
They found that all of the species isolated have sensitivity for enrofloxacin, fluorphenikol and ciprofloxacin; and also for amoxicillin, ampicillin, bacitracin, erythromycin, fucidic acid, gentamicin, chloramphenicol, lincomycin, nalidixic acid, neomycin, novobiocin, oxytetracycline, cefoxitin and sulfamethoxazole-trimethoprim at varying levels.
Novobiocin discs were used to distinguish Staphylococcus saprophyticus, which is resistant to Novobiocin in culture, from other coagulase-negative Staphylococci (CoNS).
5 % + Novobiocin - PNP: p-Nitrophenyl; NaCl: sodium chloride; (+) positive test; (-) negative test.
Each 25 g sample of thawed ground beef was macerated in a stomacher (Bagmixer, Saint Nom, France) for 120 s with 225 mL of modified EC medium (Becton-Dickinson, Sparks, MD) with 8 mg/L novobiocin (mECMn).
5] cells/reaction were collected, washed with PBS and incubated with or without MDR inhibitors (verapamil for P-gp, NIK-571 for MRP1, and novobiocin for BCRP) in the presence of the eFluxx-ID[R] Green probes for 30 min at 37[degrees]C and then evaluated by FACS analysis immediately.
Novobiocin and kaempherol were used as acceptor moleculesfor activity tests.
04 U), mannitol fermentation on Mannitol Salt Agar (MSA) (Merck, Darmstadt, Germany), urease activity, nitrate reduction, novobiocin resistance, phosphatase, deoxyribonuclease (DNase) test and carbohydrate (xylose, sucrose, trehalose and maltose, fructose, lactose, mannose) fermentation tests [29].
1 mL of this sample was added to two broth cultures (Selenite cysteine and Tetrathionate broth) that contained iodine and novobiocin, then was incubated at 35 [degrees]C and 41.