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 (no͞o′klē-ās′, -āz′, nyo͞o′-)
Any of several enzymes, including the endonucleases and the exonucleases, that hydrolyze bonds between nucleotides in nucleic acids.


(Biochemistry) any of a group of enzymes that hydrolyse nucleic acids to simple nucleotides


(ˈnu kliˌeɪs, -ˌeɪz, ˈnyu-)

any enzyme that catalyzes the hydrolysis of nucleic acids.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.nuclease - general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units
endonuclease - a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes
exonuclease - a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
Tenders are invited for subministrament dassajos per the technique of pcr to real temps basat in the chemistry of the nuclease, according to the specifications of the ppt, to make available to the idibaps investigators that the requereixin pels seus projectes de recerca.
Both firms have agreed to utilise Sangamo Therapeutics' zinc finger nuclease technology platform to develop cancer treatments.
Quantitative real-time PCR (qPCR), in particular 5' nuclease assays such as qPCR assays, is commonly used for SNP genotyping as it allows accurate, high-throughput, and inexpensive genotyping from very little sample material.
Genomic DNA of LVS was twofold diluted in nuclease free water with initial DNA concentration of 164 ng/ L and PCR was performed as per optimized conditions (George 2005; Woubit et al.
HNH nuclease is reported to be involved in cleavage of complementary strand while Ruvc cleaves the non-complementary strand resulting in the blunt end formation which after re-union gives frame shift mutations or indels [9]
These genome editing tools includes meganucleases (2), zinc finger nucleases (ZFNs) (3,4), transcription activator-like effector nucleases (TALENs) (5,6), and most recently the RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR) Cas9 nuclease (Cas stands for CRISPR-associated) (7,8).
It represents the intersection of two powerful technologies--lentiviral delivery and efficient Cas9 nuclease for gene knockout.
The global genome engineering market or genome editing market segmentation is based on technologies (clustered regularly interspaced short palindromic repeats, transcription activator-like effector nuclease, zinc finger nuclease), applications (animal genome engineering, cell line engineering, plant genome engineering), end users (academics, clinical research organizations, pharmaceutical and biotechnology companies).
Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection.
Likewise, it was discovered another nuclease activity associated with secreting granules by cytotoxic monocytes of CD14+ and CD16+ phenotypes in patients with autoimmune diseases such as severe diseases and multiple sclerosis [17].
When deployed, a combination of a DNA-snipping enzyme called a nuclease and a targeting strand of RNA called a guide RNA (gRNA) hunt down the viral genome and excise the HIV-1 DNA.