Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog
reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
Reverset: Nucleoside Analog
Active Against Resistant Viruses
ACH-126,443 (L-Fd4C) nucleoside analog
RT inhibitor Phase 1
Clevudine is an oral, once-daily nucleoside analog
drug candidate for the treatment of HBV that was shown to be well tolerated and potent in previously completed clinical studies.
Sapacitabine (CYC682), an orally-available cell cycle modulating nucleoside analog
, is in Phase 2 studies for the treatment of acute myeloid leukemia in the elderly and cutaneous T-cell lymphoma (CTCL).
NASDAQ: CYCC, NASDAQ: CYCCP) announced today that it will report results from a Phase I pharmacologic trial of sapacitabine (CYC682), a novel orally-available nucleoside analog
, in patients with advanced leukemias or myelodysplastic syndromes (MDS), at the American Society of Clinical Oncology's (ASCO) Annual Meeting at McCormick Place in Chicago.
Nasdaq: CYCC) (Nasdaq: CYCCP) announced today that the company has initiated a multicenter randomized Phase II clinical trial of sapacitabine (CYC682), an orally available nucleoside analog
, in patients with advanced cutaneous T-cell lymphoma (CTCL).
Evoltra([R])(clofarabine) is a next generation purine nucleoside analog
Sapacitabine (CYC682) is an orally-available, cell cycle modulating nucleoside analog
is in Phase I clinical trials for the treatment of cancer.
The protective effect of antiretroviral treatment was found only for protease inhibitors, not for nucleoside analog
IFN-a is a protein that nonspecifically stimulates the immune system, while ribavirin is a nucleoside analog
that works in concert with IFN-a to control the infection.
In its 600-person phase III trial for those without prior treatment, Gilead is comparing tenofovir directly to the nucleoside analog
d4T, each combined with the nucleoside analog
3TC and the NNRTI efavirenz.