Arrowhead (ARWR) announced that Janssen Pharmaceuticals, part of Johnson & Johnson (JNJ), has begun dosing in a Phase 2b study, or REEF-1, of different combination regimens, including JNJ-3989 and/or JNJ-6379, and a nucleoside analog
, or NA, for the treatment of chronic hepatitis B virus infection.
A recent study led by Niels Pedersen DVM, PhD, at the University of California, Davis, investigated the efficacy of the nucleoside analog
GS-441524, which has previously been shown to inhibit FIP viral growth in cultured cells, in cats with naturally occurring wet form or dry form FIP.
According to the company, LONSURF consists of a thymidine-based nucleoside analog
, trifluridine, and the thymidine phosphorylase (TP) inhibitor, tipiracil, which increases trifluridine exposure by inhibiting its metabolism by TP.
The current hepatitis B market contains mainly nucleoside analog
reverse transcriptase inhibitors, nucleotide analogs, and interferons -
Cordycepin (3'-deoxyadenosine), a nucleoside analog
, was first isolated from C.
BNO-1055 attenuates uptake of nucleoside analog
drugs and modulates their effect
Benefits and Risks of nucleoside analog
therapy for hepatitis B.
The novel nucleoside analog
R1479 (4\'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
Sapacitabine (CYC682), an orally-available nucleoside analog
, will be entering Phase 3 development for the treatment of acute myeloid leukemia (AML) in the elderly under a Special Protocol Assessment agreement with the U.S.
Telbivudine (Tyzeka[R], Idenix Pharmaceuticals) is a thymidine nucleoside analog
with selective activity against HBV (Lai et al., 2007).
The nucleoside analog
ribavirin is an antiviral drug with broad-spectrum activity against RNA and DNA viruses.
ATC is a new nucleoside analog
that is intended for use in patients who have developed viral resistance to existing drugs.