nucleoside analog


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Related to nucleoside analog: Purine nucleoside phosphorylase

nucleoside analog

n.
Any of a group of synthetic compounds that are structurally similar to natural nucleosides and interfere with DNA or RNA synthesis, used as antiviral and anticancer drugs.
References in periodicals archive ?
Arrowhead (ARWR) announced that Janssen Pharmaceuticals, part of Johnson & Johnson (JNJ), has begun dosing in a Phase 2b study, or REEF-1, of different combination regimens, including JNJ-3989 and/or JNJ-6379, and a nucleoside analog, or NA, for the treatment of chronic hepatitis B virus infection.
A recent study led by Niels Pedersen DVM, PhD, at the University of California, Davis, investigated the efficacy of the nucleoside analog GS-441524, which has previously been shown to inhibit FIP viral growth in cultured cells, in cats with naturally occurring wet form or dry form FIP.
According to the company, LONSURF consists of a thymidine-based nucleoside analog, trifluridine, and the thymidine phosphorylase (TP) inhibitor, tipiracil, which increases trifluridine exposure by inhibiting its metabolism by TP.
The current hepatitis B market contains mainly nucleoside analog reverse transcriptase inhibitors, nucleotide analogs, and interferons -
The novel nucleoside analog R1479 (4\'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
Sapacitabine (CYC682), an orally-available nucleoside analog, will be entering Phase 3 development for the treatment of acute myeloid leukemia (AML) in the elderly under a Special Protocol Assessment agreement with the U.S.
Telbivudine (Tyzeka[R], Idenix Pharmaceuticals) is a thymidine nucleoside analog with selective activity against HBV (Lai et al., 2007).
The nucleoside analog ribavirin is an antiviral drug with broad-spectrum activity against RNA and DNA viruses.
ATC is a new nucleoside analog that is intended for use in patients who have developed viral resistance to existing drugs.

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