nucleoside reverse transcriptase inhibitor

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nucleoside reverse transcriptase inhibitor

n. Abbr. NRTI

Any of a group of antiviral drugs, such as stavudine, that interfere with the activity of the enzyme reverse transcriptase, are structural analogs of natural nucleosides, and are used chiefly to treat HIV infection.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs

NRTI

AZT, Retrovir, ZDV, zidovudine - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow

drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV

3TC, lamivudine - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV

reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV

References in periodicals archive ?

Biktarvy combines the novel, unboosted integrase strand transfer inhibitor, or INSTI, bictegravir with the demonstrated safety and efficacy profile of the Descovy dual nucleoside reverse transcriptase inhibitor, or NRTI, backbone and is the smallest INSTI-based triple-therapy STR available.

Gilead announces China NMPA approval for Biktarvy

The recommended regimen based on two NRTI (Nucleoside reverse transcriptase inhibitor) plus one NNRTI (Non-nucleoside reverse transcriptase inhibitor) or boosted Protease inhibitor.

Evaluation of the incidence of vertical transmission of HIV infection from seropositive mother to baby with art (intervention with nevirapine)

EFdA is a nucleoside reverse transcriptase inhibitor (NRTIs).

Improved, '60,000 times more potent' compound to effectively treat HIV

Mitochondrial toxicity due to drugs of the nucleoside reverse transcriptase inhibitor (NRTI) class may add to this effect, (23) resulting in lipoatrophy.

HIV-associated lipodystrophy syndrome: an accelerated form of the metabolic syndrome of insulin resistance due to altered fat distribution

Ed4T, which was developed by Yale University, Kagoshima University and Showa University, is a nucleoside reverse transcriptase inhibitor with enhanced anti-HIV-1 activity.

Oncolys Biopharma, Yale University Conclude Licensing Agreement in AIDS Drug Development

Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.

Victim of drugs' success?

SPD754, a nucleoside reverse transcriptase inhibitor (NRTi), has already successfully completed a Phase IIa trial in 63 HIV-infected patients.

AVEXA IN-LICENSES PHASE II HIV DRUG FROM SHIRE

India's patent office rejected claims by Gilead on Tenofovir - a nucleoside reverse transcriptase inhibitor, which is a frontline drug against HIV/AIDS in poor countries - and by Tibotec on Darunavir, a newer and more expensive protease inhibitor used as a second-line drug.

India says no to AIDS drug patents, reaffirms role as 'pharmacy' of poor countries

All patients had been treated for at least 12 months (but not during the 6 months prior to study enrollment) with one of the thymidine nucleoside reverse transcriptase inhibitor (tNRTI) drugs that have been linked to lipoatrophy, said Dr.

Diabetes drug improves lipoatrophy in HIV

Zidovudine is in the nucleoside reverse transcriptase inhibitor class of drugs.

New products target variety of ailments

* The FDA approves the nucleoside reverse transcriptase inhibitor (NRTI), lamivudine (Epivir, 3TC), by accelerated approval.