nucleoside reverse transcriptase inhibitor


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nucleoside reverse transcriptase inhibitor

n. Abbr. NRTI
Any of a group of antiviral drugs, such as stavudine, that interfere with the activity of the enzyme reverse transcriptase, are structural analogs of natural nucleosides, and are used chiefly to treat HIV infection.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
AZT, Retrovir, ZDV, zidovudine - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
3TC, lamivudine - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV
reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor, or INSTI, bictegravir with the demonstrated safety and efficacy profile of the Descovy dual nucleoside reverse transcriptase inhibitor, or NRTI, backbone and is the smallest INSTI-based triple-therapy STR available.
The recommended regimen based on two NRTI (Nucleoside reverse transcriptase inhibitor) plus one NNRTI (Non-nucleoside reverse transcriptase inhibitor) or boosted Protease inhibitor.
EFdA is a nucleoside reverse transcriptase inhibitor (NRTIs).
Mitochondrial toxicity due to drugs of the nucleoside reverse transcriptase inhibitor (NRTI) class may add to this effect, (23) resulting in lipoatrophy.
Ed4T, which was developed by Yale University, Kagoshima University and Showa University, is a nucleoside reverse transcriptase inhibitor with enhanced anti-HIV-1 activity.
Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.
SPD754, a nucleoside reverse transcriptase inhibitor (NRTi), has already successfully completed a Phase IIa trial in 63 HIV-infected patients.
India's patent office rejected claims by Gilead on Tenofovir - a nucleoside reverse transcriptase inhibitor, which is a frontline drug against HIV/AIDS in poor countries - and by Tibotec on Darunavir, a newer and more expensive protease inhibitor used as a second-line drug.
All patients had been treated for at least 12 months (but not during the 6 months prior to study enrollment) with one of the thymidine nucleoside reverse transcriptase inhibitor (tNRTI) drugs that have been linked to lipoatrophy, said Dr.
Zidovudine is in the nucleoside reverse transcriptase inhibitor class of drugs.
* The FDA approves the nucleoside reverse transcriptase inhibitor (NRTI), lamivudine (Epivir, 3TC), by accelerated approval.

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