nucleoside reverse transcriptase inhibitor

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nucleoside reverse transcriptase inhibitor

n. Abbr. NRTI

Any of a group of antiviral drugs, such as stavudine, that interfere with the activity of the enzyme reverse transcriptase, are structural analogs of natural nucleosides, and are used chiefly to treat HIV infection.

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Noun

nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs

NRTI

AZT, Retrovir, ZDV, zidovudine - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow

drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV

3TC, lamivudine - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV

reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV

References in periodicals archive ?

EFdA is a nucleoside reverse transcriptase inhibitor (NRTIs).

Improved, '60,000 times more potent' compound to effectively treat HIV

Ed4T, which was developed by Yale University, Kagoshima University and Showa University, is a nucleoside reverse transcriptase inhibitor with enhanced anti-HIV-1 activity.

Oncolys Biopharma, Yale University Conclude Licensing Agreement in AIDS Drug Development

Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.

Victim of drugs' success?

As an initial HIV treatment, the nucleoside reverse transcriptase inhibitor ("nuke") Zerit (d4T) has been downgraded from a "preferred" HIV med to an "alternative" HIV med because of increasing reports of side effects, especially the association with lipoatrophy (fat wasting).

Update to HIV treatment guidelines

SPD754, a nucleoside reverse transcriptase inhibitor (NRTi), has already successfully completed a Phase IIa trial in 63 HIV-infected patients.

AVEXA IN-LICENSES PHASE II HIV DRUG FROM SHIRE

The most recent update contains information about the newly licensed nucleoside reverse transcriptase inhibitor, abacavir ([Ziagen.

Availability of Updated HIV Treatment Guidelines

If successfully developed and approved by regulatory authorities, the treatment is to offer an option to HIV patients to switch from a standard three-drug therapy to a two-drug, nucleoside reverse transcriptase inhibitor sparing antiviral regimen.

Janssen R&D Ireland collaborates with ViiV Healthcare

The guidelines advocate initial treatment regimens that consist of two nucleoside reverse transcriptase inhibitors (NR-TIs) plus either the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz or a ritonavir-boosted protease inhibitor (PI/r).

Guidelines endorse earlier treatment of HIV

Rio DE JANEIRO -- The novel nucleoside reverse transcriptase inhibitor Reverset is poised to become the newest member of the oldest class of antiretroviral agents, with researchers reporting its promise for HIV-infected patients for whom current antiretroviral regimens have failed and who have NRTI resistance.