ochronosis


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ochronosis - an accumulation of dark pigment in cartilage and other connective tissue; usually a symptom of alkaptonuria or phenol poisoning
symptom - (medicine) any sensation or change in bodily function that is experienced by a patient and is associated with a particular disease
Translations

ochronosis

n ocronosis f
References in periodicals archive ?
HGD deficiency leads to the accumulation of homogentisic acid (HGA) that can be excreted in the urine (homogentisic aciduria) or can oxidize and polymerize to form an ochronotic pigment that is deposited in the connective tissues (ochronosis) or within the joints (ochronotic arthropathy) (1).
He listed kidney and liver diseases, skin cancer, skin thinning, cataract and exogenous ochronosis, popularly known in the local parlance as 'Nensuoben', as some of the effects of these creams and products.
Misuse, however, can lead to skin conditions such as exogenous ochronosis, a blue-black pigmentation disorder resulting from the long-term application of creams containing hydroquinone.
In the worst cases, people develop ochronosis - a build-up of acid that paradoxically makes the skin appear much darker.
The pigment should be differentiated from melanin; chrysiasis; ochronosis; and tetracycline, antimalarial and amiodarone hyperpigmentation.
Exogenous ochronosis, a blue-black darkening of the skin, is a risk of long-term hydroquinone use.
Other complaints were darkening of urine color (100%), ochronosis 4 (11.1%) (Figure 1), arthralgia 6 (16.7%), and arthritis 3 (8.1%).
Mid- and long-term side effects are milia formation, paradoxical post-inflammatory hyperpigmentation (PIH), exogenous ochronosis (especially in dark phototypes).
It occurs in a variety of conditions, such as previous trauma (tendon rupture or repeated microtrauma) [9], postarthroplasties [10], vasculopathies, central nervous system injury [11], burn injury [12], metabolic conditions, such as diabetes, Wilson's disease and ochronosis, DISH (diffuse idiopathic skeletal hyperostosis), and seronegative arthropathies [13].
The dangers associated with skin lightening include severe skin conditions, including eczema, warts, acne, and ochronosis, a form of hyper-pigmentation which causes the skin to turn a dark purple shade (Adebajo 2002; Ajose 2005; Lewis et al.
The World Health Organization (WHO) has reported that Hydroquinone is a hazardous substance and could cause side effects leading to ochronosis, the accumulation of melanin pigments in some tissues such as joints and cartilages, apart from skin allergies in most cases.
The World Health Organisation has reported that hydroquinone is a hazardous substance and could cause side effects leading to ochronosis, the accumulation of melanin pigments in some tissues such as joints and cartilages, apart from skin allergies in most cases.