Octreotide, which is a synthetic cyclic octapeptide
, is a somatostatin analogue.
Pyrrolobenzodiazepines (PBDs), derivatives of naturally occurring tricyclic antibiotics, duocarmycins, anthracyclines, a-amanitin (a bicyclic octapeptide
from the fungus Amanita), and topoisomerase inhibitors including SN-38 are categorized as TIC payloads (1,164).
GSS has been associated with many different point mutations or insertional mutations of octapeptide
repeats, and D178N has not been identified in GSS. Limbic DWI or FLAIR hyperintensities can be found in up to 50% of cases.
LS301 is cyclic octapeptide
(D-Cys-Gly-Arg-Asp-SerPro-Cys)-Lys-OH that binds specifically to integrins expressed by tumor cells but not normal.
ACE is a peptidyl dipeptidase A and primarily cleaves a decapeptide (angiotensin-I) to an octapeptide
(angiotensin-II) which is a potent vasoconstrictor.
ACE is a zinc-containing metallopeptidase that catalyzes the conversion of the angiotensin I-inactive decapeptide to angiotensin II-potent vasopressor octapeptide
. This reaction promotes vasoconstriction and hydrolysis of the vasodilator bradykinin [2-4].
The purification procedure utilized the affinity of the octapeptide
repeats of the protein in the N-terminal segment for nickel and the use of histidine tag was avoided .
The ACE produces an octapeptide
called Ang II, a larger angiopeptide whose biological function is mediated by the receptors [AT.sub.1]R and [AT.sub.2]R that are involved in the signaling pathways of survival, cell division, differentiation, the vasopressor effect, hypertrophy, and the modulation of oxidative stress in the I/R process [20, 21].
Lanreotide is also a synthetic octapeptide
and it can be adminstered every 28 days.
Inhibition of coronary artery transplant atherosclerosis in rabbits with angiopeptin, an octapeptide
. Atherosclerosis 1989; 78: 229-236, doi: 10.1016/0021-9150 (89)90228-1.
phalloides contains the alpha variety of amanitin, a cyclic octapeptide
thought to be the primary agent of toxicity in humans (2).
Ang I, in turn, is hydrolyzed at its carboxy terminal by angiotensin converting enzyme (ACE), which is present within the endothelium of most blood vessels, to form the active octapeptide
angiotensin II (Ang II).