Olfaction and mortality Aside from olfaction's potential to predict disease, otherstudies have shown that olfactory impairment
increases the risk of death in older adults.
(OI), or poor sense of smell, is an understudied public health problem among older adults.
Uchihara et al., "TDP-43 pathology progression along the olfactory pathway as a possible substrate for olfactory impairment
in amyotrophic lateral sclerosis," Journal of Neuropathology and Experimental Neurology, vol.
In this study we present our data about self-reported olfactory impairment
(SROI) in workers in the abrasive industry professionally exposed to the PRs.
DLB, which has shared clinical symptoms and pathological changes with PDD, is also associated with olfactory impairment
First, the odor input is transmitted to the olfactory bulb by sensory neurons, which is then decoded and recoded in the piriform cortex and finally flocks together in the hippocampus.[sup] Although the mechanisms of AD-related olfactory sensory loss have already been explored through the use of transgenic mouse models[sup] and studies have documented olfactory deficits in APP transgenic mice,[sup] the role of A[sz] in contributing to AD-related olfactory impairment
and the involvement of these cerebral regions remain largely obscure.
In a cohort study analyzing a group of IPD patients, Postuma and Gagnon identified a significant correlation between episodic verbal memory and olfactory impairment
In one study, Matthew Growdon, a fourth-year medical student at Harvard University, Boston, and his colleagues found a significant relationship between olfactory impairment
and pathologic markers of AD.
is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease.
Smoking is a strong independent risk factor of olfactory impairment
(3) probably as consequence of anatomical changes that occur in the olfactory mucosa, such as squamous metaplasia (4) and a reduction in the number and size of the olfactory vessels and cilia (5).
"Our findings suggest that while olfactory impairment
may reflect real damage to the sensory system, in some cases it may be a 'use it or lose it' phenomenon," said Dr.
A "scratch and sniff" test is available to assess the degree of olfactory impairment
, but it doesn't help diagnose the cause of the problem, Dr.