sup] Although the mechanisms of AD-related olfactory sensory loss have already been explored through the use of transgenic mouse models[sup] and studies have documented olfactory deficits in APP transgenic mice,[sup] the role of A[sz] in contributing to AD-related olfactory impairment and the involvement of these cerebral regions remain largely obscure.
In one study, Matthew Growdon, a fourth-year medical student at Harvard University, Boston, and his colleagues found a significant relationship between olfactory impairment and pathologic markers of AD.
Smoking is a strong independent risk factor of olfactory impairment (3) probably as consequence of anatomical changes that occur in the olfactory mucosa, such as squamous metaplasia (4) and a reduction in the number and size of the olfactory vessels and cilia (5).
In a study of 54 polysomnographically confirmed cases of RBD and 54 age- and sex-matched controls, marked olfactory impairment was observed in 33 of the RBD group, compared with 9 of the controls (Brain Res.
The results showed that surgery in addition to olfactory impairment had no significant effect on subject's performance and suggested that we should not provide a sham-operated group that surgical effect could be detected.