oligodendrocyte


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ol·i·go·den·dro·cyte

 (ŏl′ĭ-gō-dĕn′drə-sīt′, ō′lĭ-)
n.
Any of the neuroglial cells of the central nervous system that are responsible for the formation of myelin sheaths in the white matter and that, in the gray matter, are detectable using myelin staining techniques and may provide support for adjacent neurons.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

oligodendrocyte

(ˌɒlɪɡəʊˈdɛndrəʊsaɪt)
n
(Anatomy) anatomy a glial cell involved in the formation of the myelin sheaths of nerve cell axons
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oligodendrocyte - a cell of the oligodendroglia
glial cell, neurogliacyte, neuroglial cell - a cell of the neuroglia
oligodendria, oligodendroglia - tissue consisting of glial cells with sheetlike processes that form the myelin sheath of nerve fibers
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

ol·i·go·den·dro·cyte

n. oligodendrocito, célula de la neuroglia que participa en pocos aunque delicados procesos.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
The team, based at the Wellcome-MRC Cambridge Stem Cell Institute (University of Cambridge), studied old and young rat brains to understand the impact of age-related stiffening on oligodendrocyte progenitor cells (OPCs).
The study describes how the single-cell analyses identified a subpopulation of cells critical to glioblastoma formation, the early primitive progenitor cells of oligodendrocyte brain cells, pri-OPC progenitors, according to Q.
Our culture system is usable as an alternative procedure which leads to significant enhancement in generation of oligodendrocyte from BMSC.
Multiple sclerosis is a demyelinating disorder which causes severe disability in patients due to loss of myelin sheaths around axons as a result of the injury or death of adult oligodendrocytes. (1) During the development of glial cells, oligodendrocytes differentiate from oligodendrocyte precursor cells (OPCs) through the involvement of special intrinsic transcription factors such as oligodendrocyte transcription factor 2 (OLIG2), Nkx-2.2, and Sry-related HMg-Box gene 10 (SOX10); in addition, some inhibitory signaling pathways including Wnt and Notch, which are the result of their final performance, play critical roles in OPC differentiation into oligodendrocytes and the myelination process.
Convelo Therapeutics is developing brain-penetrant small molecule therapeutics that stimulate oligodendrocyte differentiation and myelin regeneration from oligodendrocyte precursor cells (OPCs).
Under the agreement, the company has exclusive rights in all fields of use for a patent family that claims a method of improving recovery in a patient that has suffered an ischemic stroke by administering to the patient stem cell-derived oligodendrocyte progenitor cells.
Constant research suggests that TXA302 achieves its effects on angiogenesis and plasticity in the brain by stimulating endothelial progenitor cells and oligodendrocyte progenitor cells, leading to increases in brain-derived neurotrophic factor and other factors.
In this paper, we review recent evidence regarding human leukocyte antigen (HLA) genotyping and myelin oligodendrocyte glycoprotein (MOG) antibodies--the two most important candidate biomarkers for early-onset MS--as well as their potential application in the diagnosis and treatment of MS.
Neuron (axon) and oligodendrocyte (myelin) cross talk is also required to maintain proper metabolic function of axons.
Moyon's thesis characterized the transcriptomic profile of oligodendrocyte progenitor cells--the main remyelinating cells of the central nervous system, after injury and among the aging and those with MS.
David Rowitch of the University of California at San Francisco to devise new ways to generate oligodendrocyte precursor cells (OPCs) from human skin cells.