The team, based at the Wellcome-MRC Cambridge Stem Cell Institute (University of Cambridge), studied old and young rat brains to understand the impact of age-related stiffening on oligodendrocyte
progenitor cells (OPCs).
The study describes how the single-cell analyses identified a subpopulation of cells critical to glioblastoma formation, the early primitive progenitor cells of oligodendrocyte
brain cells, pri-OPC progenitors, according to Q.
Our culture system is usable as an alternative procedure which leads to significant enhancement in generation of oligodendrocyte
Clinical and Prognostic Evaluation of Myelin Oligodendrocyte
Glycoprotein Autoimmunity in the Central Nervous System
Multiple sclerosis is a demyelinating disorder which causes severe disability in patients due to loss of myelin sheaths around axons as a result of the injury or death of adult oligodendrocytes
. (1) During the development of glial cells, oligodendrocytes
differentiate from oligodendrocyte
precursor cells (OPCs) through the involvement of special intrinsic transcription factors such as oligodendrocyte
transcription factor 2 (OLIG2), Nkx-2.2, and Sry-related HMg-Box gene 10 (SOX10); in addition, some inhibitory signaling pathways including Wnt and Notch, which are the result of their final performance, play critical roles in OPC differentiation into oligodendrocytes
and the myelination process.
Convelo Therapeutics is developing brain-penetrant small molecule therapeutics that stimulate oligodendrocyte
differentiation and myelin regeneration from oligodendrocyte
precursor cells (OPCs).
Under the agreement, the company has exclusive rights in all fields of use for a patent family that claims a method of improving recovery in a patient that has suffered an ischemic stroke by administering to the patient stem cell-derived oligodendrocyte
Constant research suggests that TXA302 achieves its effects on angiogenesis and plasticity in the brain by stimulating endothelial progenitor cells and oligodendrocyte
progenitor cells, leading to increases in brain-derived neurotrophic factor and other factors.
In this paper, we review recent evidence regarding human leukocyte antigen (HLA) genotyping and myelin oligodendrocyte
glycoprotein (MOG) antibodies--the two most important candidate biomarkers for early-onset MS--as well as their potential application in the diagnosis and treatment of MS.
Neuron (axon) and oligodendrocyte
(myelin) cross talk is also required to maintain proper metabolic function of axons.
Moyon's thesis characterized the transcriptomic profile of oligodendrocyte
progenitor cells--the main remyelinating cells of the central nervous system, after injury and among the aging and those with MS.
David Rowitch of the University of California at San Francisco to devise new ways to generate oligodendrocyte
precursor cells (OPCs) from human skin cells.