oligomerization


Also found in: Medical, Encyclopedia, Wikipedia.

o·lig·o·mer

 (ə-lĭg′ə-mər)
n.
A polymer consisting of at least 2 and as many as 100 monomers.

o·lig′o·mer′ic (-mĕr′ĭk) adj.
o·lig′o·mer′i·za′tion n.

oligomerization

(ˌɒlɪˌɡɒməraɪˈzeɪʃən) or

oligomerisation

n
(Chemistry) chem the production of an oligomer from monomers bonding together, or an occurrence of this formation
Translations
oligomérisation
References in periodicals archive ?
Previous authors have emphasized the difficulty of measuring clones of FLCs, as their structures are heterogeneous and can be modified through pH, polymerization, and oligomerization (5-8).
Whatever the case, human synthetic NT-proBNP is a monomer, and the potential confounding issue of analyte oligomerization is not a problem for this analyte.
Another study demonstrated that the N-terminal region of proBNP contains a leucine zipper-like sequence motif that may induce peptide oligomerization in plasma under physiologic conditions, producing either a trimer or tetramer of proBNP and a trimer of NT-proBNP (2).
These measurements support the hypothesis of oligomerization of the glycoprotein.
It is nevertheless important to emphasize that such oligomerization may have a major influence on antibody detection and assay performance.
Because real-time fluorescence monitoring was not available on the plate reader, we used agarose gel analysis and signal measurements of the Universal Amplifluor-labeled PCR amplicons to assess the contribution of primer oligomerization in no-template samples to the fluorescent signals.
Moreover, the prosequence contains a leucine zipper-like sequence motif that has been reported to induce oligomerization of the N-terminal fragments of proBNP and pro-atrial natriuretic peptide (proANP) in plasma (31).
The protein consists of a highly charged acidic amino-terminal domain, which can interact with components of the transcriptional machinery, and a highly charged basic carboxy-terminal region, which can mediate oligomerization, nuclear localization, and possibly the recognition of damaged DNA.