p-F11 also promotes adiponectin oligomerization
and secretion (Figure 2).
The aggregation process is initiated by oligomerization
of the soluble monomers, followed by their association into protofibrils and finally the bunch of fibrils forms the amyloid plaques .
Another research has considered the protein-protein interfaces in transmembrane domains of outer membrane proteins, with the purpose of determining their oligomerization
triggers binding of a Bacillus thuringiensis cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains.
Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization
, and aggregation: amyloid-beta destabilization promotes annular protofibril formation.
Excessive production of reactive oxygen species, mitochondrial dysfunction leading to apoptosis, accumulation and oligomerization
of the protein alpha-synuclein, and defective protein disposal by the ubiquitin proteasome system are involved in the complex web of events mediating nigral cell demise.
Innate immune cells sense danger signals by activation of membrane-bound pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), and cytoplasmic PRRs, including nucleotide-binding oligomerization
domain (NOD)-like receptors (NLRs) and RIG-I-like receptors (RLRs), to initiate immune responses .
Upon ROS stimulation, Trx is converted to the oxidized form and is dissociated from ASK1, which allows tight oligomerization
through the N-terminal coiled-coil domain and thereby activates ASK1 by inducing autophosphorylation of ASK1.
Glyoxylate was a good starting point because of the possibility that it could be produced by oligomerization
of carbon monoxide under potentially prebiotic conditions.
Coverage progresses from fundamentals of catalysis through organometallic-catalyzed reactions, carbonylation of methanol, C-C coupling reactions, and hydrogenation, oligomerization
, and polymerization of olefins.
Previously ligation of cytokine to its corresponding receptor was believed to be the initiating event in receptor oligomerization
and subsequent signal transduction.
A recent report in Clinical Chemistry addressed the possibility of natriuretic peptide oligomerization
in a study that used a recombinant N-terminal proBNP peptide (possessing a glycine-serine N-terminal extension) spiked into 3 matrices (2).