oncogene

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on·co·gene

 (ŏn′kə-jēn, ŏng′-)
n.
1. Any of various mutated genes that cause the transformation of normal cells into cancerous cells.
2. Any of various viral genes that transform host cells into cancerous cells.

[Greek onkos, mass, tumor; see oncology + gene.]

oncogene

(ˈɒŋkəʊˌdʒiːn)
n
(Genetics) any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
[C20 from Gk onkos mass, tumour + gene]

on•co•gene

(ˈɒŋ kəˌdʒin)

n.
any gene that is a causative factor in the initiation of cancerous growth.
[1965–70]

on·co·gene

(ŏn′kə-jēn)
A gene containing a mutation in its DNA that causes normal cells to turn into cancerous ones. See Note at cancer.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oncogene - a gene that disposes normal cells to change into cancerous tumor cellsoncogene - a gene that disposes normal cells to change into cancerous tumor cells
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Translations
References in periodicals archive ?
Detection of E6 and E7 oncogenes appears to be a more specific means of identifying those women who are truly at risk.
Using new methods to find geneticmutations, two groups of scientists have found more evidence that genes called oncogenes are a significant cause of cancer.
The In-Cell HPV probes are designed to detect messenger RNA (mRNA) of the E6 & E7 oncogenes, and provide an alternative to HPV DNA testing to screen women for HPV infections.
It is generally assumed that specific oncogenes must be activated for cancer to develop, Kennedy says.
Medarex expects to use its UltiMab Human Antibody Development System(SM) to generate fully human antibodies based on three novel oncogenes discovered by Tularik.
Extra copies of other oncogenes areassociated with recurrences of neuroblastoma, a rare childhood cancer (SN: 4/20/85, p.
com) functions as a specialized center of excellence focused on clinical research and development of cancer diagnostic tests based on oncogenes, tumor suppressor genes and other gene targets whose proteins are directly involved in tumor growth or metastasis.
The tests incorporate the so-called C-melting technology, based on PNA and able to find multiple mutated oncogenes in real-time.
In addition, the company said the primary objectives of the study are to assess correlation of mutation frequencies in BRAF, KRAS and PIK3CA oncogenes with tumor load, to monitor disease progression and to assess genomic changes as a patient undergoes therapy.
We now know that miRNAs in fact act as oncogenes and tumor suppressors.
There are relatively few oncogenes that are critical to breast cancer growth, and only one other breast cancer oncogene has been identified in the last 6 years.
NuPotential's cell programming technology involves the use of proprietary small molecule-based cell reprogramming processes for generating patient-specific iPS cells instead of commonly-used retroviruses or cancer-inducing oncogenes.