Patients will be treated with Turning Point's investigational MET inhibitor, TPX-0022, which has been designed with a unique, compact macrocyclic structure to not only target MET, but also modulate the tumor microenvironment by inhibiting CSF1R and SRC oncogenic
signaling to potentially improve therapeutic outcomes.
The peer-reviewed manuscript, "Sensitivity of next-generation sequencing assays detecting oncogenic
fusions in plasma cell-free DNA," was released online ahead of publication in Lung Cancer.
According to the company, BTX-A51 is a small molecule, oral multi-kinase inhibitor that appears to block a specific leukemic stem cell target (CK1-alpha) as well as super-enhancer targets (CDK7/CDK9) preventing transcription of key oncogenic
2, 2018 (HealthDay News) -- Continuing regular cytology screening up to age 75 years or performing an exit human papillomavirus (HPV) test to confirm the absence of oncogenic
HPV strains past the age of 55 years offers preventive benefit for older women with a cervix, according to a study published online Nov.
Researchers from Arizona State University want to know if we humans, as a species, are oncogenic
, a term for species that causes cancer in others.
Objective: To determine the frequency of different pathological conditions associated with oncogenic
viruses and estimate overall disease burden in our patient population.
Three of them were of genotype 6, whereas four were of genotype 16, 18, 31, 81 that are known as highly oncogenic
. There were no correlations between the presence of HPV and the patient's age, the presence of reflux esophagitis or H.
Tumor-induced osteomalacia (TIO) or oncogenic
osteomalacia is an underrecognized paraneoplastic syndrome presenting with hypophosphatemia and typical manifestations of osteomalacia .
In these cells, while stem cell potential is maintained, the oncogenic
protein responsible for disease is lost ("oncogene suppression") [33, 34].
However, distinguishing oncogenic
fusion mutations, whose functions are critical for cancer initiation, progression, and metastasis, remains a big challenge.
Each time, she tested positive for oncogenic