Arf gene loss enhances oncogenicity
and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.
Despite the advantages of induced pluripotent stem (IPS) cells over embryonic stem cells, certain barriers like low reprogramming efficiency, concerns regarding oncogenicity
and teratoma formation limit their clinical utility.
(12) Additionally, implantation of human ASCs (hASCs) show few side effects such as oncogenicity
or immune rejection, suggesting that autologous hASCs pass through the blood brain barrier and that this treatment is safe in humans.
BK and JC human polyomaviruses and simian virus 40: natural history of infection in humans, experimental oncogenicity
, and association with human tumors.
MAP involves mining a proprietary algorithm for allosteric oncogenes, validating their oncogenicity
, elucidating the precise mechanism by which a given oncogene is allosterically activated, and designing drugs specific for these groups of allosteric mutations.
Trefoil factor-1 (TFF1) enhances oncogenicity
of mammary carcinoma cells.
Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity
in vivo as indicated by studies in syngeneic or immune-deficient mice, where reinsertion of various CEACAM1 isoforms in colorectal or prostate CEACAM1-negative tumor cells proved CEACAM1-L expression to be essential for maintaining a normal phenotype with the inhibition of allograft or xenograft tumor development [27, 28].
They are not only of low immunogenicity and oncogenicity
, but they can also selectively migrate to tumor sites [2, 3, 9, 10].
Manabe et al., "KLF5 regulates the integrity and oncogenicity
of intestinal stem cells," Cancer Research, vol.
Yan et al., "B-cell lymphoma 6 protein stimulates oncogenicity
of human breast cancer cells," BMC Cancer, vol.
The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity
. Toxicol Appl Pharmacol 55:207-219, PMID: 7423514.
Because EBV infection early in life increases its oncogenicity
, it is vitally important to prevent transmission to the very young.