The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity
Because EBV infection early in life increases its oncogenicity
, it is vitally important to prevent transmission to the very young.
In absence of a clear mechanistic link, the activity of resveratrol may be partially dependent upon an impaired expression of certain miRNAs associated with inflammatory and tumor suppression effects (miR-663), proinflammatory effects (miR-155), or oncogenicity
Today Lasso is a restricted-use pesticide due to its oncogenicity
Kim and Diehl reported that overexpression of cyclin D1 is not sufficient to drive oncogenic transformation although cyclin D1 overexpression is clearly implicated in cancer, but nuclear retention of cyclin D1 may be critical for the manifestation of its oncogenicity
(Kim and Diehl 2009).
miR-134 induces oncogenicity
and metastasis in head and neck carcinoma through targeting WWOX gene.
Earlier studies have demonstrated that sialidase treatment of cancer cells reduces their electrophoretic mobility, causes a substantial decrease in oncogenicity
, and increases immunogenicity in animals.
Our results further confirmed the oncogenicity
of HBV, which supports the viewpoints that the expressions of HBV proteins themselves have oncogenic potency and that the integration of HBV DNA into the host genome promotes carcinogenic mechanisms in the host genome (26-29).
Cacodylic Acid: Combined Chronic Feeding and Oncogenicity
Study in The Rat.
8 More than 200 HPV types have now been identified and these types are classified as high- risk and low-risk based upon their cervical cancer oncogenicity
Cancer, biology, and genetics researchers from North America and Europe discuss the MYC protein and its regulation of expression, protein-protein interactions, genomic recognition, and transcriptional functions; MYC's biological activities in normal cellular processes, including its roles in pluripotency, vertebrate and invertebrate development, DNA replication, apoptosis, and metabolism; the activities that make it a major driver in oncogenicity
, including its regulatory mutations, induction of genomic instability, cell competition, and metabolic programming; specific examples of its roles in Burkitt lymphoma, medulloblastoma, and neuroblastoma; and approaches to tumors, including synthetic lethal screens and targeted chemotherapy.
Human papillomaviruses : basic mechanisms of pathogenesis and oncogenicity