The novelty of our approach stems from (1) its use of primary t cells, (2) its capacity to probe the architecture and dynamics of signalosomes resulting from t cell-antigen presenting cell encounters, (3) the attention we pay to the stoichiometry of the studied signalosomes, A key parameter largely ignored in previous studies, And (4) its multidisciplinary nature straddling molecular and organismal
scales.our specific aims are:aim 1.
The text then shifts to coverage of organismal
stressors beginning with abiotic ones, including oxygen, light, water, minerals and xenobiotic compounds, as well as the information processing to respond to such.
Each section builds from simple physics to discussion of organismal
movements such as circulation, flying, swimming, breathing, erectile function, and ambulation.
Biology of body systems and developmental, organismal
, and population biology came last in the books, where it is more likely to be skipped if instructors do not have enough time over the course of the semester or quarter.
"Programmable data storage within the DNA of living cells would seem an incredibly powerful tool for studying cancer, aging, organismal
development and even the natural environment," said Endy.
"In a number of these trackways, the animals alternate their limbs, which suggested that they must have been made by tetrapods walking on a solid substrate," said Melina Hale, PhD, associate professor of Organismal
Biology and Anatomy.
Six chapters discuss key target systems and organismal
effects, including liver toxicity, the osmoregulatory system, chemical carcinogenesis of fishes, and toxicity resistance.
Most of the accounts are written by former students of cellular and molecular biology (and not even one organismal
or population biologist, if psychologists and physicians are also excluded).
Understanding requires the integration of environmental history with a phylogenic organismal
history, and with an appreciation for the physiology of organisms in the environment - all three placed within an ecological context.
However, the theme of the "balance" school must have been sweet music to an organismal
biologist who had long since written of the need to understand the genetic basis of organismal
integration (Mayr 1942, p.
Objective: Replication of the genome is of critical importance for cell proliferation and organismal
Next, the cellular, organismal
, and ecological impacts of toxin release in biological systems are discussed, featuring several of the toxins discussed in the first part.