(Norflex, Flexon), procyclidine (Kemadrin), and trihexyphenidyl (Artane, Trihexane).
Muscle Relaxants: Cyclobenzaprine, Dicyclomine, Orphenadrine
The oral tablets contain 50 mg of Orphenadrine
Citrate, 770 mg of Aspirin and 60 mg of Caffeine.
Most reported cases of M/A to date have occurred among patients with psychiatric illness because anticholinergic medications, including trihexyphenidyl, benztropine, biperiden, procyclidine, and orphenadrine
, were commonly prescribed for the management of first-generation and high dopamine D2-affinity antipsychotic-induced extrapyramidal symptoms (EPS).
It also interferes with cellular metabolic processes, interacts with membrane ion channels (Sztajnkrycer, 2002; Chateauvieux et al., 2010), and induces oxidative stress by compromising the antioxidant status of the neuronal tissue (Chaudhary and Parvez, 2012); caffeine in the CNS competitively antagonizes adenosine receptors, inhibits phosphodiesterase, stimulates catecholamine release, and increases free calcium and intracellular cAMP (Fredholm et al., 1999); orphenadrine
chloride competitively antagonizes acetylcholine binding at the neuroreceptor sites and induces necrosis in liver (Sangster et al., 1978; Ekwall et al., 1998)).
Richter, "Fast determination of codeine, orphenadrine
, promethazine, scopolamine, tramadol, and paracetamol in pharmaceutical formulations by capillary electrophoresis," Journal of Separation Science, vol.
Laboratories, chest radiography, and a head computational tomography were done with normal findings; orphenadrine
and opioids were ordered, and was discharge home.
Two days before admission, medications were administered for back pain: aceclofenac (selective cyclooxygenase-2 [COX-2] inhibitor), orphenadrine
(muscle relaxant), and alibendol (digestant).
* Keterolac (Toradol), meclofenamate (Meclomen), carisoprodol (Soma), orphenadrine
(Norflex), cyclobenzaprine (Flexeril), and metaxolone (Skelaxin) for tension headaches
After that initial visit, the patient and family elected to try other pharmacologic options, including orphenadrine
, dextromethorphan, and mexiletine.
ABSTRACT: New, rapid, simple, and precise reversed-phase high-performance liquid chromatographic method was validated and developed for the simultaneous determination of caffeine, Paracetamol and Orphenadrine
After a cervical spine radiograph, a diagnosis of cervical muscle strain and radiculopathy was made, for which the patient received injections of orphenadrine
(a muscle relaxant) and ketolorac (a nonsteroidal anti-inflammatory drug).