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n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.

hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pathology) pathol overgrowth and thickening of the outer layer of the skin
hyperkeratotic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌhaɪ pərˌkɛr əˈtoʊ sɪs)

1. proliferation of the cells of the cornea.
2. a thickening of the horny layer of the skin.
hy`per•ker`a•tot′ic (-ˈtɒt ɪk) adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
Other lesions found included moderate multifocal chronic lymphoplasmacytic interstitial nephritis, diffuse hepatic mild lipidosis, erosive glossitis and focal orthokeratotic hyperkeratosis.
Cross sections of the tarsi showed moderate to severe orthokeratotic hyperkeratosis, in some cases associated with Knemidocoptes species-like mites.
Skin compromised by a malignant neoplasm lesion of epithelial origin, formed by papillomatous epidermal acanthosis, with orthokeratotic hyperkeratosis and infiltrating tracts of epidermoid differentiated cells.
Histopathology of skin biopsy from the right axillary region and right thigh showed orthokeratotic hyperkeratosis, acanthosis, and papillomatosis of the stratum spinosum.