One patient with squamous cell lung cancer presented with hypertrophic
osteoarthropathy (HOA), i.e., clubbing of the fingers and toes associated with bony pain of the extremities.
Saima Yousuf talked about Charcot
osteoarthropathy in Type 2 diabetes persons presenting to specialized diabetic center.
Calcaneal ultrasonometry in patients with Charcot
osteoarthropathy and its relationship with densitometry in the lumbar spine and femoral neck and with markers of bone turnover.
Total destruction of a weight bearing joint is marked by bony destruction, Charcot
osteoarthropathy is most overlooked serious limb-threatening complication of diabetes - Prof.Bilal Bin Younis bone resorption and eventual deformity.
Periosteal new bone, however, also can be associated with chronic skin ulcers, hemorrhage, metabolic disease, hypertrophic
osteoarthropathy, and joint, vascular, or neoplastic disease (Aufderheide and Rodriguez-Martin 1998:179; Waldron 2009:115-117; Weston 2012).
Extrathoracic symptoms have also been reported; these include weakness, fever, weight loss, nocturnal sweating, chills, digital clubbing or hypertrophic
osteoarthropathy. (3) Hypoglycemia has also been reported related to the production by the tumor of insulin-like growth factor II (IGF-II), which causes an increased glucose utilization and an impaired growth hormone counter-regulatory response to hypoglycemia.
(25,27) Uncommonly, finger clubbing, hypertrophic pulmonary
osteoarthropathy, and refractory hypoglycemia related to the production of an insulin-like growth factor have been reported.
Hypertrophic pulmonary
osteoarthropathy secondary to bronchial adenocarcinoma and coexisting pulmonary tuberculosis: a case report.
The role of proinflammatory cytokines in the cause of neuropathic
osteoarthropathy (acute Charcot foot) in diabetes.
Thalassemic syndromes Heterozygous beta thalassemia Other hemoglobinopathies Artifact in the presence of Hb S Some Hb variants with thalassemic phenotype Acquired conditions Megaloblastic anemia Hyperthyroidism Pseudoxanthoma elasticum Hypertrophic
osteoarthropathy Treatment-related conditions Antiretroviral therapy in patients with HIV
It occurs in lung cancer patients with hypertrophic pulmonary
osteoarthropathy.
(1) PDP is the primary form of hypertrophic
osteoarthropathy (HOA) and accounts for 5% of all cases of HOA.