osteoclast


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os·te·o·clast

 (ŏs′tē-ə-klăst′)
n.
1. A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.
2. An instrument used in surgical osteoclasis.

[osteo- + Medieval Latin -clastēs, breaker (from Late Greek -klastēs, from Greek klastos, broken, from klān, to break).]

os′te·o·clas′tic adj.

osteoclast

(ˈɒstɪəʊˌklæst)
n
1. (Surgery) a surgical instrument for fracturing bone
2. (Physiology) a large multinuclear cell formed in bone marrow that is associated with the normal absorption of bone
ˌosteoˈclastic adj

os•te•o•clast

(ˈɒs ti əˌklæst)

n.
1. a skeletal cell that functions in bone formation.
2. a surgical instrument for effecting osteoclasis.
[1870–75; osteo- + -clast < Greek klastós broken]
os`te•o•clas′tic, adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.osteoclast - cell that functions in the breakdown and resorption of bone tissue
bone cell - a cell that is part of a bone
Translations
Osteoklast
luunsyöjäsolu

os·te·o·clast

n. osteoclasto, célula gigante multinucleada que participa en la formación de tejido óseo y reemplaza al cartílago durante la osificación.
References in periodicals archive ?
Corticosteroids, such as prednisolone, can negatively impact bone health by increasing osteoclast apoptosis, reducing ossification and leading to increased bone resorption and osteoporosis.
At some point, the epithelium of the main pancreatic duct clearly displayed cytological atypia and became stratified with a sudden shift to pleomorphic mononuclear round and spindle cells chaperoned by benign looking osteoclast giant cells.
CCL3 also functions as a chemotactic molecule for mature osteoclasts (13) and osteoclast precursor cells (14).
Brown et al., "Osteoclast formation from circulating precursors in osteoporosis," Scandinavian Journal of Rheumatology, vol.
* Suitable ratio for co-culturing peripheral blood mononuclear cells with differentiated osteoblasts was 1 osteoclast: 2 osteoblasts.
TNF-[alpha] and IL-6 possess the same bone resorbing stimulating activity, and these three cytokines increase the osteoclast response to RANKL, which leads to osteolysis.
Peles et al., "Bortezomib inhibits osteoclast activity in patients with multiple myeloma," Clinical Lymphoma & Myeloma, vol.
* Most anti-osteoporosis drugs act mainly by stopping osteoclast activity, with little impact on bone-forming osteoblasts.
In bone tissue, PTH increases osteoclast formation and bone resorption by regulating the receptor activator of nuclear factor kappa B ligant (RANKL)/osteoprotegerin (OPG) expressed in osteoblasts.
In the current study, we attempted to estimate whether liensinine and nuciferine could prevent breast cancer-mediated bone destruction by examining their effects on the growth, motility, and invasiveness of human triple-negative MDA-MB-231 and human estrogen receptor-positive MCF-7 cells, RANKL-induced osteoclast differentiation in bone marrow macrophages (BMMs), and mature osteoclast-mediated bone resorption.
miRNA mimics thus can be used for rebalancing inflammatory and bone cell phenotypes in conditions such as RA [9], promoting osteoblast differentiation, and inhibiting osteoclast activity.