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Related to osteopontin: Osteocalcin, Osteonectin


A phosphorylated glycoprotein that is produced by bone, is abundant in bone mineral matrix, and accelerates bone regeneration and remodeling. It is also produced in other tissues and plays a role in the progression of many diseases, including certain cancers.

[osteo- + Latin pōns, pont-, bridge; see pent- in Indo-European roots + -in.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Its concentration in serum rises only in cases of increased remodeling of bone.8 The tissue mineralization stimulating effect of BALP is achieved mainly through inactivation of pyrophosphate and osteopontin, which are themselves mineralization inhibitors.9 Calcium and phosphate are important components of bony inorganic matrix and major factors in maintenance of bone health.
Studies have shown that salivary acid phosphatase, alkaline phosphatase, osteopontin and osteocalcin levels had significantly improved following topical administration of melatonin.
Prespecified statistical analyses of PFS according to expression of two plasma biomarkers, TGF receptor III and osteopontin, also did not achieve statistical significance.
The HART AKI test algorithmically interprets six clinical and protein variables (history of diabetes, blood urea nitrogen to creatinine ratio, C-reactive protein, osteopontin, CD5 antigen-like, and Factor VII).
While many factors contribute to blood cell differentiation, secretion of a protein called osteopontin was most highly correlated with better survival rates in mice treated with MSCs.
To determine that differentiation had happened, the specific gene of osteogenic cells, osteopontin and collagen type I, was tested in both groups via RT-PCR.
27 Masloub SM, Abdel-Azim AM, Elhamid ESA: CD10 and osteopontin expression in dentigerous cyst and ameloblastoma, Diagnostic pathology 2011, 6:1
Some studies have reported that resveratrol can up-regulate translation of Bone Morphogenic Protein-2 (BMP-2), Bone Morphogenic Protein-7 (BMP-7) and OPN (Osteopontin).
In a previous study, researchers demonstrated that virus-mediated expression of osteopontin and insulin-like growth factor (IGF1) promoted the regrowth of brain-derived corticospinal tract (CST) axons and functional recovery of CST-dependent motor function following an incomplete SCI lesion.
However, recent studies have shown that CAC is an organized, regulated, proactive process.[4] CAC involves expression of an altered phenotype of vascular smooth muscle cells (VSMCs) and expression of bone-related proteins such as osteopontin, osteoprotegerin (OPG), osteocalcin, and bone morphogenetic proteins (BMPs).
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