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Related to osteopontin: Osteocalcin, Osteonectin


A phosphorylated glycoprotein that is produced by bone, is abundant in bone mineral matrix, and accelerates bone regeneration and remodeling. It is also produced in other tissues and plays a role in the progression of many diseases, including certain cancers.

[osteo- + Latin pōns, pont-, bridge; see pent- in Indo-European roots + -in.]
References in periodicals archive ?
4] CAC involves expression of an altered phenotype of vascular smooth muscle cells (VSMCs) and expression of bone-related proteins such as osteopontin, osteoprotegerin (OPG), osteocalcin, and bone morphogenetic proteins (BMPs).
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
10) Osteopontin, recognized as one of the spontaneous autoimmune models of SLE, may also be related.
Pre-osteoblastik hucreler kullanilarak yapilmis bir calismada borun kollajen-I, kemik sialoproteinleri, osteokalsin, osteopontin ve hucre disi matriks proteinlerine ait mRNA ekspresyonlarina etki ettigi, kemik morfogenez proteinleri (Bone morphogenetic proteins, BMP) seviyelerini arttirdigi belirlenmistir ve borun kemik gelisiminde kullanilabilecegi vurgulanmistir (41).
Nucleotide sequencing of bovine osteopontin gene showed a novel DNA polymorphism 37421762 (C>A) in the 3'-untranslated region (3'-UTR) of the gene.
As shown in the figure, blockade of IL-6 signaling lead to a broad range of changes in biomarkers such as sICAM-1, VEGF, osteonectin, osteopontin, osteocalcin, and bone alkaline phosphatase.
We investigated the role of osteopontin (OPN) and stathmin-1 (STHMN1) in metastatic castrate-resistant (mCRPC).
SPP1 levels in cell culture media was assessed using the human osteopontin (OPN) Quantikine[R] ELISA Kit (D0ST00; R&D Systems).
They found that lead exposure induced an oxidative stress response in the cells, and identified two proteins involved in the process: SPP1, or osteopontin, and NRF2.
The presence of biomarkers, such as carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), CA 125, CA 19-9, alpha-fetoprotein (AFP), CYFRA 211, and osteopontin, has been shown to differentiate between malignant and benign PE.
Hyperglycemia in diabetic patients inhibit the proliferation and differentiation of periodontal cells, delayed periodontal regeneration and healing due to decreased function of transcription factor (Runx)-2, osteocalcin and osteopontin expression.
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