She had no relevant personal or family history, and no history of head trauma or use of ototoxic
Hadi said there are different causes of hearing impairment, including genetic and acquired, adding that the acquired one could be owing to ototoxic
(caused by any medication), disease or infection and trauma.
It can be triggered by a blast of loud noise, infections, misuse of ototoxic
drugs, effects of toxin or by head injury,' he said.
It can be hereditary or acquired as can be triggered by a blast of loud noise, infections, misuse, use of ototoxic
drugs, the effects of toxin or by head injury.
We excluded external ear, middle ear and other ear diseases as well as systemic diseases that may affect hearing, such as otitis externa, impacted cerumen, otitis media, noise damage, ototoxic
drug poisoning, inner ear malformation, diabetes mellitus, hypertension and chronic nephritis.
Tuberculosis (TB) patients on treatment are at high risk for sudden and profound hearing loss as a consequence of the ototoxic
properties of some of the lifesaving drugs they take.
Patients not willing to undergo pure tone audiometry testing, patients with a history of ear discharge, perforated tympanic membrane or any chronic ear discharge, history of intake of ototoxic
drugs continuously for 6 months and prolonged history of exposure to noise (e.
Ion homeostasis, immune suppression, and free radical scavenging effects of those agents made them to be used to protect cochlea, particularly in ototoxic
drug use and acoustic trauma .
Neither patient had been exposed to ototoxic
medications, nor did they have a history of excessive noise exposure.
3) There are several factors as the possible causes of hearing loss in kidney failure, including the use of ototoxic
drugs, electrolyte imbalance, hypertension, (6,7) and hemodialysis treatment.
The parents were also administered a survey form which queried the prenatal, perinatal, and postnatal diseases associated with SNHL and the use of ototoxic
drugs by the mother during pregnancy.
A growing body of evidence from in vitro and animal studies has demonstrated ototoxic
effects of lead, cadmium, and mercury; possible underlying mechanisms of their ototoxic
effects include oxidative stress through depletion of glutathione and protein-bound sulfhydryl groups and related reductions in blood flow and lipid peroxidation in the cochlea, leading to latency in auditory nerve conduction and to an elevation of auditory thresholds (Park 2015; Prasher 2009).