Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.


Having a toxic effect on the structures of the ear, especially on its nerve supply.

o′to·tox·ic′i·ty (-tŏk-sĭs′ĭ-tē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Medicine) damage to the ear
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Protective effect of edaravone against tobramycin-induced ototoxicity. Acta Otolaryngol 2009 Jan;129(1):8-13.
The present study analysed, in an animal experimental model, the time course of the pathogenic mechanisms of noise-induced cochlear damage and the efficacy of the antioxidant drug N-acetylcysteine in reducing noise ototoxicity. Animals were divided into two groups, exposed to noise one treated with N-acetylcysteine for 3 days and one (the control group) with saline.
The patient who is prescribed neomycin should be assessed for concurrent renal impairment along with liver dysfunction as use of this medication may increase the risk for ototoxicity and nephrotoxicity.
The risk of ototoxicity is one stumbling block in the widespread use of topical antibiotics.
And he'll be that way for the rest of his life because his condition, called ototoxicity, cannot be cured.
Drug-induced hearing loss results in ototoxicity, and more than 130 drugs are reported to be toxic to the inner ear.
The mechanism of aminoglycoside ototoxicity is mediated by disruption of mitochondrial protein synthesis and the formation of free oxygen radicals.
Ototoxicity is a well-known adverse effect of platinum-based chemotherapy drugs, resulting in hearing loss and tinnitus.
A literature review investigating cisplatin ototoxicity in children and childhood cancer survivors was conducted.
(the US), a preclinical CRO specializing in hearing research and the development of tinnitus announced its partnership with Sinclair Research (the US), a nonclinical research organization (CRO) offering animal efficacy models, IND-enabling and specialty toxicology services and GLP to offer GLP ototoxicity testing services collaboratively.
(NASDAQ: FENC; TSX: FRX), a specialty pharmaceutical company focused on the development of PEDMARK (a unique formulation of sodium thiosulfate (STS)) for the prevention of platinum-induced ototoxicity in pediatric patients, today reported its business update and financial results for the second quarter ended June 30, 2019.