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A white poisonous glycoside, C29H44O12, extracted from the seeds of certain African trees of the genera Strophanthus and Acokanthera, that is used as a dart poison in some parts of Africa and has been used to treat congestive heart failure.

[From French ouabaïo, from Somali wabayo.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Elements & Compounds) a poisonous white crystalline glycoside extracted from certain trees and used as a heart stimulant and, by some African tribes, on poison darts. Formula: C29H44O12.8H2O
[C19: from French ouabaïo, from Somali waba yo native name of tree]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(wɑˈbɑ ɪn)

a white crystalline glycoside, C29H44O2, extracted from the seeds or wood of certain African trees and used as a poison on the tips of arrows or in medicine as a heart stimulant.
[1890–95 < French ouaba(ïo) (< Somali waabayyo arrow poison) + -in1]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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There is evidenceiii that patients with high levels of a substance called endogenous ouabain may have an increased risk of developing kidney damage.
However, the brevetoxins were not included in the present study, as the neuro-2a bioassay is already able to discriminate between the presence of DSPs and the neurotoxic brevetoxins, i.e., DSPs can be detected without addition of ouabain and veratridine, while the brevetoxins can only be detected in the neuro-2a bioassay by adding low concentrations of ouabain and veratridine (Manger et al., 1995; Dickey et al., 1999).
Thus, anandamide (10 mg/kg, i.p.) was shown to reduce neuronal excitotoxic injury following intracerebral injection of ouabain in neonatal rats (64).
(12,13) It has been demonstrated that the tachycardia induced by positive inotropic agents including digitalis glycosides and ouabain enhanced myocardial oxygen consumption.
The [Mg.sup.2+]-ATPase activity was detected in the presence of 1 mM ouabain, while the total ATPase activity was determined in the presence of 100 mM NaCl, 5 mM KCl, 6 mM Mg[Cl.sub.2], 0.1 mM EDTA, 30 mM Tris HCl (pH: 7.4).
schneideri methanolic extract (50 [micro]g/mL of granular gland secretion) responded with an increase in quantal content (release of acetylcholine) that was inhibited with a non-toxic concentration of ouabain (1 [micro]g/mL), an inhibitor of the [Na.sup.+]/ [K.sup.+]-ATPase, after 5 min prior to incubation, indicating that these effects were prevented through the inhibition of [Na.sup.+]-[K.sub.+]-ATPase activity of muscle motor innervation.
Complex assessment of distinct cognitive impairments following ouabain injection into the rat dorsoloateral striatum.
An African perennial vine called strophanthus makes seeds that contain the active ingredient referred to as g-strophanthin in Europe and ouabain in the US.
[5.] Leenen FH (2010) The central role of the brain aldosterone -"ouabain" pathway in salt-sensitive hypertension.
Effects of ouabain and diphenylhydantoin on transmembrane potentials, intracellular electrolytes, and cell pH of rat muscle and liver in vivo.
The rate of ion transport by [Na.sup.+],[K.sup.+] -ATPase was calculated from the difference between the slope of the linear regression describing the relationship between [.sup.86][Rb.sup.+] transport and incubation time in the presence and absence of 2 mmol [l.sup.-1] ouabain. This concentration of ouabain is known to saturate the inhibition of in vivo [Na.sup.+],[K.sup.+]-ATPase in larvae of C.
Despite its history being harvested from African plants to stop an enemy's heart with the shot of a bow, ouabain is also a steroid that the human body naturally produces.