Primary Hyperoxaluria is a rare autosomal recessive disorder leading to markedly elevated levels of endogenous oxalate
in plasma and urine.
About 80% of stones consist of Calcium and Oxalate
. Most other stone are composed of uric acid -- end product of protein metabolism.
Dicerna recently presented updated data from the PHYOX1 Phase 1 clinical trial of DCR-PHXC, which reported substantial post-dose reductions in 24-hour urinary oxalate
levels in adult and adolescent study participants with PH1 and PH2.
Moreover, urolithiasis may be due to increased excretion of certain stone forming substances, as calcium, oxalate
, phosphate, uric acid and sodium; and decreased excretion of certain stone inhibiting materials as citrate, magnesium, sulfate and pyrophosphates.
Summary: Poly(1,4-cyclohexanedimethylene oxalate
) was synthesized from oxalyl chloride and cis/trans-1,4-cyclohexandimethanol.
A recent review on clinical outcomes in EH patients with oxalate
nephropathy found that renal replacement therapy was required in greater than 50% of patients.
The most common types of crystals are struvite and calcium oxalate
, and these can be distinguished by their unique shapes under a microscope.
Kidney stones form when there is too much calcium, oxalate
, or uric acid in your urine.
levels are found in Taro (Colocasia esculenta), Sweet potato (Ipomoea batatas), and Yam (Dioscorea alata) tubers (275-574 mg/100 g fresh weight) (1) Oxalate
oxidase (EC 220.127.116.11), an enzyme found in nature degrades oxalate
to hydrogen peroxide and carbon dioxide (2) oxalate
oxidase activity has been detected in Barley (3), Beet (4), Maize (5), sorghum (6) and wheat (7) Functionally diverse protein super family known as Cupins, concerned with cell wall, fungal defence, salt tolerance and floral induction are found to possess oxalate
oxidase activity (8).
Crystals of calcium oxalate
(CaOx), in various forms, shapes, sizes and crystallinity, are common constituents of plants (Franceschi and Nakata 2005; Raman et al.
PH is a rare autosomal recessive disorder leading to elevated levels of endogenous oxalate
causing kidney deterioration and a gradual calcification of soft tissues.