oxidative phosphorylation


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oxidative phosphorylation

n.
The process in cell metabolism by which respiratory enzymes in the mitochondria synthesize ATP from ADP and inorganic phosphate during the oxidation of NADH by molecular oxygen.

oxidative phosphorylation

n
(Biochemistry) the process by which the energy liberated by oxidation of metabolites is used to synthesize the energy-rich molecule ATP

ox′idative phosphoryla′tion



n.
the aerobic synthesis, coupled to electron transport, of ATP from phosphate and ADP.
[1950–55]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oxidative phosphorylation - an enzymatic process in cell metabolism that synthesizes ATP from ADP
citric acid cycle, Krebs citric acid cycle, Krebs cycle, tricarboxylic acid cycle - in all plants and animals: a series of enzymatic reactions in mitochondria involving oxidative metabolism of acetyl compounds to produce high-energy phosphate compounds that are the source of cellular energy
biological process, organic process - a process occurring in living organisms
References in periodicals archive ?
The ratio between state 3 and state 4 rates (respiratory control ratio, RCR), which represents coupling between electrons transport and oxidative phosphorylation, was determined.
Clearance of palmitic acid is largely dependent on metabolic reactions in which beta oxidation and oxidative phosphorylation produce enormous amounts of ROS and exhaust the supply of antioxidants in pancreatic [beta] cells.
Moreover, we summarize evidence from AD post-mortem brain as well as cellular and animal AD models showing that A [beta] and TAU protein trigger mitochondrial dysfunction through a number of pathways, such as impairment of oxidative phosphorylation, elevation of reactive oxygen species production, alteration of mitochondrial dynamics, and interaction with mitochondrial proteins.
Mitochondria in the samples from children with autism were less efficient at creating energy through oxidative phosphorylation.
These reactions are executed through a series of intracellular biochemical processes (glycolysis, Krebs cycle, electron transport, and oxidative phosphorylation) resulting in the production of ATP and the release of heat and chemical by-products (lactate and [CO.sub.2]) into the extra-cellular environment (Wu et al.
Both large deletions and point mutations in mtDNA have been identified in patients with characteristic oxidative phosphorylation defects.
Dhalla, "Effect of adrenochrome on adenine nucleotides and mitochondrial oxidative phosphorylation in rat heart," The Canadian Journal of Cardiology, vol.
The citric acid cycle (also known as the Krebs cycle) then takes over inside the mitochondria to convert the acetyl-CoA into the reduced form of nicotinamide adenine dinucleotide (NADH) and the reduced form of flavin adenine dinucleotide (FADH2), which are important in a process known as oxidative phosphorylation (OXPHOS).
Oxidative phosphorylation abnormalities impair energetics in the SN mitochondria, also intensifying oxygen free radical generation.
These signs can be explained by the effects of PCP itself, that is, uncoupling of oxidative phosphorylation in mitochondria (3).
In 1985, Coleman and Blass observed elevated levels of lactate in the plasma of four patients with autism, suggesting a defect in oxidative phosphorylation [12].