oxidized LDL cholesterol

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Noun1.oxidized LDL cholesterol - LDL cholesterol that has been bombarded by free radicals; it is thought to cause atherosclerosis
LDL cholesterol - the cholesterol in low-density lipoproteins; the `bad' cholesterol; a high level in the blood is thought to be related to various pathogenic conditions
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Many studies show that oxidized LDL cholesterol leads to atherosclerosis.
A clinical study in Canada discovered that the short-term consumption of cranberry juice resulted in a significant reduction of oxidized LDL cholesterol in the blood.(7) During the research, 21 healthy men drank 250 mL of cranberry juice, twice a day, for 2 weeks.
Oxidized LDL cholesterol is known to increase the risk of heart disease.
Oxidized low-density lipoprotein (LDL cholesterol) directly and indirectly promotes the production of inflammatory cytokines, the migration of monocytes into the subepithelial space of vessels, and the formation of macrophages that take up the oxidized LDL cholesterol and form foam cells that build an atherosderotic plaque.
No other statistically significant changes were seen at 52 weeks for nontraditional cardiovascular markers such as precursor brain natriuretic protein, or oxidized LDL cholesterol.
Kappagoda added that the group taking 300 mg of grape seed extract also had reduced serum oxidized LDL cholesterol levels.
Less oxidized LDL cholesterol means less accumulation of deadly plaque even if the total cholesterol has not been reduced.
Diets with generous amounts of vegetable protein may have the same effect (reduced triglyceride levels), as is seen with using more monounsaturated fats and may even offer more benefits since oxidized LDL cholesterol was also lowered.
Scientists think that biologically active flavonoids from red grapes may work in three ways to lower the risk of heart disease: by reducing production of harmful oxidized LDL cholesterol, boosting beneficial HDL cholesterol, and cutting blood platelet aggregation.