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Related to oxoacid: Binary acid


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Anti-mitochondrial antibodies (AMA) directed against the E2 subunit of pyruvate dehydrogenase (PDH-E2) which is a member of the inner mitochondrial membrane-expressed oxoacid dehydrogenase complex, and ketoglutarate dehydrogenase are present in 95% of the patients3.
Thus the 2 oxoacid dehydrogenases--pyruvate dehydrogenase, branched chain keto acid dehydrogenase and glycine decarboxylase dysfunction in Neanderthals and autism can contribute to neuropsychiatric, neurodegenerative, cancer, autoimmune disease and metabolic syndrome.
tBHP is able to inhibit Complex I-driven respiration in mitochondria, as well as some oxoacid dehydrogenases [24-26].