Generally cellular specimens with abundant lymphocytes or lymphoid tangles and follicular cells showing a variety of changes in the same nodule, including variable oxyphilic
change, nuclear pleomorphism, and nuclear anisocytosis.
suggested , only cases exhibiting lymphoplasmacytic infiltration with germinative center formation, oxyphilic
cell metaplasia (Hurthle), atrophy, and thyroid follicle fibrosis (also called "signs of chronic oxyphilic
lymphocytic thyroiditis") were diagnosed as HT histopathologically, provided that the AMA or ATA status was positive.
Variants include microscopic (<1 cm), widely invasive, oncocytic (Hurthle cell, Ashkenazy cell, oxyphilic
cell) (figure 3), insular, trabecular, solid, signet-ring, and clear-cell types, among others.
Hidradenoma papilliferum with oxyphilic
metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus.
1 Histologic features of HT include diffuse infiltration of lymphoid cells usually with formation of lymphoid follicles, varying degrees of fibrosis, oxyphilic
change or squamous metaplasia in the epithelial cells.
However several unusual variants of MTC including encapsulated tumors, anaplastic variants, oxyphilic
variants, tumors with mixed follicular and parafollicular cell differentiation as well as melanin producing MTCs have been reported.
In the parathyroids these are called as oxyphilic
cells, hurthle cells in thyroid and oncocytes in pituitary, salivary glands, breast and kidney.
This fish is an oxyphilic
species and prefers waters with temperature below 20[degrees]C.
Chronic interferon-alpha exposure leads to changes in thyroid gland, including enlarged follicles lined by thickened granular and oxyphilic
thyrocytes with diffuse mononuclear infiltrates of the stroma (8).
adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces.
The malignant category of follicular-patterned thyroid lesions includes FC (including its oxyphilic
variant, also known as Hurthle cell carcinoma) (13) and FVPTC.