Large cells with eosinophilic cytoplasm can be seen in oxyphilic
clear cell renal cell carcinomas.
An association between the MIBI absorption in parathyroid adenoma and the amount of oxyphilic
cells consisting of a number of mitochondria was suggested.
Propensity score matching analysis of the prognosis for the rare oxyphilic
subtype of thyroid cancer (Hurthle cell carcinoma).
Prophylactic surgery is preferred in these cases since oxyphilic
and follicular cytology cannot clearly differentiate between benign and malign nodules (10-12).
Additionally, 18.5% (5/27) who had total thyroidectomy preoperative FNAC showed oxyphilic
cell in the background of either MNG or Hashimoto's thyroiditis.
(16) Minor variations of the cytomorphological features are occasionally seen due to duct cell metaplasia (mucinous, squamous, oxyphilic
and sebaceous), variable stromal cellularity, crystal deposition (tyrosine) and intranuclear cytoplasmic inclusions.
Mostly, main cells of parathyroid gland but rarely oxyphilic
cells were observed in the tissue.
Histological examination revealed only follicular and oxyphilic
variants of multifocal papillary carcinoma (at least six foci) and none of insular carcinoma, with dimensions ranging from 2 to 15 mm, without signs of hematogenic, lymphatic, or perineural permeation, as well as no signs of invasion of the capsule or extrathyroidal extension, with resection margins uninvolved by tumour (pT1b[m]NxM1R0) (Figure 4).
adenomatoid tumor of the ovary: A case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces," International Journal of Gynecological Pathology, vol.
Feature Result PTC histology, n (%) 301 (89.29%) FTC histology, n (%) 36 (10.71%) Classical PTC, n (%) 124 (41.89%) Tall cells variant PTC, n (%) 37 (12.50%) Oxyphilic
variant PTC, n (%) 11 (3.72%) Follicular variant PTC, n (%) 106 (35.81%) Other PTC variants, n (%) 18 (6.08%) Unifocal tumor, n (%) 192 (57.31%) Vascular and lymphatic invasion, n (%) 56 (16.82%) Capsular invasion, n (%) 77 (23.12%) Extrathyroid invasion, n (%) 70 (21.02%) Well-differentiated tumor, n (%) 314 (92.29%) Moderately differentiated tumor, n (%) 14 (4.20%) Poorly differentiated tumor, n (%) 5 (1.5%) Table 3: Significant findings from a comparison of categorical variables and anthropometric data.
The disease generally originates from chief or oxyphilic
cells, and has been rarely (1%) determined to originate from the hyperplasia seen in water-clear cells.
Hurthle cells are considered an oxyphilic
variant of follicular epithelial cells and are characterized by large-sized cells with polygonal to square shapes, distinct borders, hyperchromatic nuclei with prominent nucleoli, and abundant eosinophilic granular cytoplasm owing to the accumulation of large numbers of intracytoplasmic mitochondria.