Many publications have used immortalized cells as MSC surrogates, but they may not mean much if they don't have functionally accurate p53
," said Siddaraju Boregowda, one of the study's two lead authors.
protein is a critical tumor suppressor in the cell, and genetic mutations that occur in cancer cause a loss of its function in regulating proliferation arrest and cell death.
Cells with loss of p53
function and abnormal expression of p53
are speculated to undergo malignant transformation.
Keywords: S100B, P53
, brain tumours, interrelationship of biomarkers.
The report provides comprehensive information on the Cellular Tumor Antigen P53
(Tumor Suppressor P53
or Antigen NY-CO-13), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Accordingly we examined the expression of P53
and Caspase 3 in the livers of mice having transperitoneally injected Ehrlich Ascites carcinoma cells and treated with Tetrodotoxin.
dependent histone deacetylase, and the p53
gene was the first SIRT1 deacetylation nonhistone target to be discovered [4, 5].
RT4 cells have wild-type p53
and functional ATM proteins, while T24 cells harbor mutant p53
Recent data have shown that, in addition to losing transcriptional function, mutant P53
gains oncogenic functions termed GOF (gain of function) that drive cell migration, invasion, and metastases.
However, this mutated protein could not interfere with binding of RAD51 to GST-WT p53
in MDA-MB-468 cell line by in vitro experiment.
Immunohistochemistry (IHC) for P53
and Ki-67 were performed on representative blocks of paraffin embedded tissue.
High prevalence of p53
alterations have been investigated in HCC as a consequence of chronic hepatitis B.