pancreatic fibrosis


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Noun1.pancreatic fibrosis - the most common congenital disease; the child's lungs and intestines and pancreas become clogged with thick mucus; caused by defect in a single gene; no cure is known
monogenic disease, monogenic disorder - an inherited disease controlled by a single pair of genes
fibrosis - development of excess fibrous connective tissue in an organ
References in periodicals archive ?
These findings suggested the goose experienced zinc toxicosis with resultant pancreatic fibrosis and insufficiency resulting in diabetes mellitus, with cerebellar degeneration and necrosis attributed to persistent hyperglycemia.
The second is the oxidative pathway, which activates the stellate cells, leading to pancreatic fibrosis. It has demonstrated that both human and rat stellate cells are activated directly by ethanol in clinically relevant concentrations that go from 10 mM (social consumption) to 50 mM (intense ethanol consumption) (Apte et al., 2000; Masamune et al., 2010).
One patient had pseudopancreatic cyst by ultrasound abdomen and one patient had pancreatic fibrosis. Pleural fluid was exudates in all the patients by Light's criteria.
Recent studies have reported that TGF-[beta] has a predominant role in the accumulation of pathological extracellular matrix in pancreatic fibrosis and chronic pancreatitis (7).
Hepatic and pancreatic stellate cells (HSCs and PSCs) have been considered to be closely associated with the pathogenesis of fibrosis, offering a hopeful therapeutic target for treating hepatic and pancreatic fibrosis. Recently, we have generated transgenic mini-pigs carrying astrocyte-specific expression of DsRed regulated by the 2.2-kb human glial fibrillary acidic protein (hGFAP) gene promoter.
Fukuta et al., "Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis," Pancreatology, vol.
Apte was the first in the world to develop a method to isolate pancreatic stellate cells (PSCs), a technique which provided a research tool for studying the path that pancreatic fibrosis (scarring of the pancreas) takes.