pantothenate


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Related to pantothenate: Calcium pantothenate, Pantothenate kinase

pan·to·then·ate

 (păn′tə-thĕn′āt′, păn-tŏth′ə-nāt′)
n.
A salt or ester of pantothenic acid.

pantothenate

(ˌpæntəˈθɛneɪt)
n
(Biochemistry) a widely occurring derivative of pantothenic acid
References in periodicals archive ?
Mild accumulation remained in the left parotid gland after oral stimulation with a mixture of ascorbic acid and calcium pantothenate (Figure 3).
Pantothenate Kinase Associated Neurodegeneration (PKAN)
Four up-regulated pathways were involved in pantothenate and CoA biosynthesis, PPAR, adipocytokine, and chemokine signaling.
Retrophin announced that the Phase 3 FORT Study evaluating the safety and efficacy of fosmetpantotenate compared to placebo in patients with pantothenate kinase-associated neurodegeneration did not meet its primary endpoint and did not demonstrate a difference between treatment groups.
The Company's approach centers on its pipeline featuring late-stage assets targeting rare diseases with significant unmet medical needs, including fosmetpantotenate for pantothenate kinase-associated neurodegeneration (PKAN), a life-threatening neurological disorder that typically begins in early childhood, and sparsentan for focal segmental glomerulosclerosis (FSGS) and IgA nephropathy (IgAN), disorders characterized by progressive scarring of the kidney often leading to end-stage renal disease.
Retrophin Inc (NASDAQ: RTRX) said the Phase 3 FORT study that evaluated the safety and efficacy of fosmetpantotenate compared to placebo in patients with pantothenate kinase-associated neurodegeneration did not meet its primary endpoint and did not demonstrate a difference between treatment groups.
However, after the fourth experimental week, the fish fed diet D0 (2.57 mg PA [kg.sup.-1] diet) started to show clinical signs of calcium pantothenate deficiency, such as lethargy, body hemorrhages, and skin desquamation, as well as epithelial detachment, bleeding and complete loss of the caudal fin preventing swimming.
Vitamins: A, 2,500 Ul; D3,600.000 Ul; E, 37.500 Ul; K3,3,750 mg; C, 50,000 mg; Bl, 4.000 mg; B2,4,000 mg; B6,4,000 mg; B12,4,000 mg; calcium pantothenate, 12,000 mg; biotin, 15 mg; acid folic, 1,250 mg; niacin, 22,500 mg.
As can be seen, the most important metabolite markers for the Alzheimer group included alanine, glutamine, serine, valine, isobutyrate, carnitine, taurine, pantothenate, glucose, asparagine, succinate, glycine, creatinine, isoleucine, pyruvate, betaine, choline, scyllo-inositol and myo-inositol.
Furthermore, there was some evidence of inadequate micronutrient intakes from the whole diet with AA-MF and GMP-MF treatments for the following micronutrients: magnesium, vitamin E, biotin, zinc, selenium, pantothenate, vitamin K, vitamin C, copper, and thiamin.