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n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.

hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pathology) pathol overgrowth and thickening of the outer layer of the skin
hyperkeratotic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌhaɪ pərˌkɛr əˈtoʊ sɪs)

1. proliferation of the cells of the cornea.
2. a thickening of the horny layer of the skin.
hy`per•ker`a•tot′ic (-ˈtɒt ɪk) adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
The epidermis of the affected area had multiple large, exophytic, pedunculated masses composed of markedly hyperplastic epithelial cells forming papillary projections with abundant orthokeratotic and parakeratotic hyperkeratosis (Figure 1, panel B).
There was extensive parakeratotic hyperkeratosis, alternated with serocelluar crusts and orthokeratotic hyperkeratosis.
Mucosa of tongue, esophagus, rumen and omasum presented mild to moderate parakeratotic hyperkeratosis. Amyloidosis was seen in the liver, especially in the periportal region, and in splenic follicles.