Vital peptides by convention display high degree of conservation in evolutionary timeframe , therefore presents them selves as an important tool for the assessment of significant events such as genome duplication, gene paralogue formation etc in the evolutionary history of the peptide.
It has been estimated that only 50% of the duplicated genes have subsequently been lost from the genome  with retained paralogues able to undergo subfunctionalisation leading to altered expression .
Plant conserved non-coding sequences and paralogue
is the gene that has the closest DNA sequence to another gene, probably because the two arise via gene duplication.
2006) found in five Chamaedorea species a third PRK paralogue
, which they identified as potentially useful for phylogenetic analysis.
Reduction of evolutionary constraints by paralogues
of class B floral homeotic genes.
HLA-C belongs to the HLA class I heavy chain paralogues
AJ428410) as a test of the presence of nuclear paralogues
Whether this may be due to paralogues
, hybridization, or other sources of systematic error (e.
Inferring evolutionary relationships among members of gene families is generally problematic because distinguishing paralogues
and orthologues is difficult without appropriate known outgroups to polarize the gene phylogeny.