system requires paralogy
, paradoxical language games with the continous
The rhetoric of social entrepreneurship: Paralogy
and new language games in academic discourse.
Genomic analysis of polygenic traits like QTLs must consider the implications of synteny and the potential importance of paralogy
, duplication, copy number, and retroviral regulators to list a few mechanisms [2, 3, 30, 31, 55].
This fallacious form of argumentation was once defended as a part of postmodernist scholarship by Lyotard (1984) as "legitimation by paralogy
Classification of these gene fragments into paralogy
groups was determined by comparison of their derived amino acid sequence, using diagnostic amino acids, to the homeodomain of known Hox and ParaHox genes.
The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy
and substrate specificities similar to mammals.
Starting by reanimating Jean-Francois Lyotard's notion of "negative dialogics" or paralogy
, Di Leo turns to poststructuralism's linguistic anti-foundationalisms, where speech or language itself can escape from set structures, determined narratives, preestablished meanings, consensual agreement, and coercions (29).
This method of legitimation, which Lyotard terms "legitimation by paralogy
," would only be possible in a situation where all actors are aware of the language game--what we have been referring to as "script" and what Agamben refers to as "the being-in-language of human beings"--they are participating in and all of the possible moves it affords them.
The validity of paralogy-based rooting methodology has proven to be severely compromised by a number of problems and artifacts of sequence analysis (e.g., long branch attraction, mutational saturation, taxon sampling, horizontal gene transfer (HGT), hidden paralogy
, and historical segmental gene heterogeneity).
This approach is embodied in a recently developed novel approach for computational annotation of gene function that incorporates information on both orthology and paralogy
and yields significantly more annotations at the same average precision than a model that includes only orthologs .
Not surprisingly, the Hsp70.c proteins clustered together phylogenetically, TbHsp70.c formed a monophyletic clade with TbgHsp70.c and a close link with TcoHsp70.c, suggesting possible paralogy
. The Hsp70.c cluster formed a closer phylogenetic relationship with the cytoplasmic Hsp70s, including inducible human Hsp70B (HsHSPA6), constitutively expressed human Hsc70 (HsHSPA8), bovine Hsc70 and plant Hsp70 than with mitochondrial Hsp70s, the NEF-acting Hsp110s, or the DnaKs (prokaryotic Hsp70 homologue) (Figure 1).
ExonIntron structure, paralogy
and sequenced regions of elongation factor-1 alpha in hexapoda.