"Acid is produced in a single cell in the stomach called the parietal cell
, which pumps the acid into the stomach.
As PPIs are membrane-permeable weak bases that accumulate in acid spaces of the active parietal cell
, they share the same pharmacodynamics.
In biopsies that contained oxyntic gastric mucosa, changes suggestive of PPI use, such as parietal cell
hyperplasia and dilated fundic glands, were seen on microscopic examination.
Histamine H2 antagonist drugs block the H2 receptor on the parietal cell
pylori is not just one organism but is very diverse in form (17) and has several adaptive features for life in the stomach: the enzyme urease to protect itself from acid by creating a cloud of ammonia, a corkscrew-like morphology that allows it to burrow into mucus, and "virulence factors" that allow it to interact closely with the host stomach to downregulate parietal cell
acid production and many other functions.
However, her histopathological evaluation of the small bowel showed villous atrophy, apoptotic bodies, and complete absence of goblet and Paneth cells; biopsies of the stomach showed an unusual pattern of injury with chronic inflammation, glandular abscesses, and parietal cell
atrophy while in the colon, there was increased apoptosis and marked loss of goblet cells and Paneth cells.
Mardh, "Major parietal cell
antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+, K+-adenosine triphosphatase of the stomach," The Journal of Clinical Investigation, vol.
hyperplasia, glandular dilatation, and fundic gland polyps are a sequence of changes that are observed in patients on long-term PPI therapy.
B2-glycoprotein I antibodies, antinuclear antibodies, anti-gastric parietal cell
antibodies, anti-Langerhans cell antibodies, anti-thyroperoxidase antibodies, anti-thyroglobulin antibodies, anti-GMI antibodies, and anti-cardiolipin antibodies were measured in patients with increased levels of GADA.
These cells divide periclinally to form a primary parietal cell
to the outside and a primary sporogenous cell to the inside (Fig.
L-thyroxine requirement in patients with autoimmune hypothyroidism and parietal cell
Complete blood count differential count folic acid vitamin B12 intrinsic factor gastric parietal cell
antibodies and holotranscobalamin II were assessed.