penicillamine


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pen·i·cil·la·mine

 (pĕn′ĭ-sĭl′ə-mēn′)
n.
A chelating agent, C5H11NO2S, that is a degradation product of penicillin and is used in the treatment of Wilson disease, refractory rheumatoid arthritis, and excess urinary excretion of cystine.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

penicillamine

(ˌpɛnɪˈsɪləˌmiːn)
n
(Pharmacology) pharmacol a metabolite of penicillin, being a pyridoxine inhibitor and chelating agent, usually used as an anti-inflammatory in the treatment of arthritis
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

pen•i•cil•la•mine

(ˌpɛn əˈsɪl əˌmin, -mɪn)

n.
a chelating agent produced by the degradation of penicillin, used esp. to treat rheumatoid arthritis and lead poisoning.
[1943]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.penicillamine - a drug (trade name Cuprimine) used to treat heavy metal poisoning and Wilson's disease and severe arthritis
medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive ?
Pemphigus vulgaris mainly develops due to adverse drug reaction (ADR) of drugs such as enalapril, captopril, penicillamine, some antibiotics, etc.
The product is prescribed to treat Wilson's Disease for patients who cannot tolerate penicillamine. It is a condition where the body stores excess copper.
Due to his blood lead level of 128 [micro]g/dl, penicillamine (250 mg qid via nasogastric tube) was administered to him.
The diagnosis of copper overload was based on an elevated hair copper concentration, increased 24-hour urinary copper excretion following a challenge with penicillamine (a copper-chelating agent), and symptomatic improvement after a course of penicillamine therapy.
According to D'Angelo, (2) copper deficiency is mainly associated with conditions such as gastric and bariatric surgery; dietary conditions like parenteral hyperalimentation; loss of proteins with enreropathies; hypoproteinemic status such as celiac disease; complications due to therapy with high doses of zinc and penicillamine; and chronic use of proton pump inhibitors.
(Chelating agents increase the urinary excretion of mercury [9] which includes thiol-based agents such as dimercaprol (British anti-Lewisite (BAL)), penicillamine, unithiol (2,3-dimercaptopropane-1-sulfonate (DMPS)), and succimer (dimercaptosuccinic acid (DMSA)).
Penicillamine challenge test in the diagnosis of Wilson's disease.
Drug-induced EPS was commonly associated with the use of penicillamine as previously observed by several reports.[sup][2]
Another important chelator, which is used in patients with severe emesis where oral administration of D penicillamine is not possible is BAL.
Some of the associated conditions can be remembered with the mnemonic MADPPORES: Marfan syndrome, Acrogeria, Down syndrome, Penicillamine, Pseudoxanthoma elasticum, Osteogenesis imperfecta, Rothmund-Thomson syndrome, Ehlers-Danlos (some forms), and Scleroderma.