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Related to penicillinases: cephalosporinase


Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.


(Medicine) any of a group of enzymes used to treat allergic reactions to penicillin
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Noun1.penicillinase - enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
These enzymes whether penicillinases or cephalosporinases lead to the development of resistance.
Meropenem is stable to hydrolysis by most beta-lactamases, including penicillinases and cephalosporinases produced by gram-negative and gram-positive bacteria, with the exception of carbapenem hydrolyzing beta-lactamases.
The main resistance mechanism of bacteria to penicillin is based on its own production of enzymes, the penicillinases, which degrade the penicillin before it can have effect (Daum, 2007).
Oxacillinase- (OXA-10- and OXA-2-) and PSE-type penicillinases were also detected in the present study.
observed that for Enterobacteriaceae with IRT, the vitek 2 AES achieved 60% full and 40% partial agreement with the genotypic analysis, and penicillinases were considered as the alternative cause for the partial agreement strains.
Semisynthetic penicillins, resistant to staphylococcal penicillinases, such as methicillin and oxacillin became an option for the treatment of penicillin-resistant strains.

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