pepsinogen

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pep·sin·o·gen

(pĕp-sĭn′ə-jən)

The inactive precursor to pepsin, formed in cells of the mucous membrane of the stomach and converted to pepsin by autocatalysis in the presence of hydrochloric acid.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

pepsinogen

(pɛpˈsɪnədʒən)

(Biochemistry) the inactive precursor of pepsin produced by the stomach

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

pep•sin•o•gen

(pɛpˈsɪn ə dʒən, -ˌdʒɛn)

n.

a crystalline proenzyme of the gastric glands, converted to pepsin during digestion.

[1875–80]

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Noun

pepsinogen - precursor of pepsin; stored in the stomach walls and converted to pepsin by hydrochloric acid in the stomach

enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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pylori antibody and serum pepsinogen (PG) has been implemented in Nishitokyo city from 2011 on the initiative of Nishitokyo Medical Association.[20] In comparison of the conventional mass screening, the ABC method not only increases the EGC detection rate but also reduces the screening cost.[21],[22],[23]

Gastric Cancer Screening by Combined Determination of Serum Helicobacter pylori Antibody and Pepsinogen Concentrations: ABC Method for Gastric Cancer Screening

Serum TFF3 was shown to be a better potential screening tool for gastric cancer than pepsinogen in Japan [11].

Screening Biomarker as an Alternative to Endoscopy for the Detection of Early Gastric Cancer: The Combination of Serum Trefoil Factor Family 3 and Pepsinogen

Flavonoid-based biocompounds were also reported to promote formation of the gastric mucosa, inhibit pepsinogen production, decrease acid mucosal secretion, and reduce ulcerogenic lesions [53].

Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds

Yuan, "Association between pepsinogen C gene polymorphism and genetic predisposition to gastric cancer," World Journal of Gastroenterology, vol.

Gastric Cancer Associated Genes Identified by an Integrative Analysis of Gene Expression Data

review the current evidence about the use of "ABC method," a combination of anti-Helicobacter pylori antibody and serum pepsinogen (PG), for gastric cancer screening.

Disease biomarkers in gastrointestinal malignancies

Secretion of peptide hormones and pepsinogen into the circulation and muriatic acid into gastric lumen decreases at H.

Serological criteria for mild, moderate and severe atrophy in atrophic gastritis

In OME patients, pepsinogen and pepsin were detected in the middle ear fluid and the possibility of gastric fluid presence in the middle ear and its role in pathogenesis of OME was proposed.

Tracing of Helicobacter pylori in patients of otitis media with effusion by polymerase chain reaction

Pepsin is a monomeric L-protein with a high percentage of acidic residues (43 out of 327) leading to a very low pH of 1.5-2.0, and is expressed as a prototype of zymogen and pepsinogen and is released by the chief cells in the stomach to degrade food proteins into peptides (Wang et al.

Alkaloids from Mahonia bealei posses anti-[H.sup.+]/[K.sup.+]-ATPase and anti-gastrin effects on pyloric ligation-induced gastric ulcer in rats

Most of the cells found in the tubular gastric glands are chief cells that secrete pepsinogen, an enzyme important for protein digestion.

Histological features of the gastrointestinal tract of wild Indonesian shortfin eel, Anguilla bicolor bicolor (McClelland, 1844), captured in Peninsular Malaysia

Kuroda et al., "Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes," Endocrine Journal, vol.

Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis

Serum IL-6 levels and pepsinogen (PG) isozymes I and II were measured using a CLEIA (chemiluminescence enzyme immunoassay).

Significant association between serum interleukin-6 and Helicobacter pylori antibody levels among H. pylori-positive Japanese adults

Inoue et al., "Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer," International Journal of Cancer, vol.