peptidase


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Related to peptidase: signal peptidase

pep·ti·dase

 (pĕp′tĭ-dās′, -dāz′)
n.

peptidase

(ˈpɛptɪˌdeɪs; -ˌdeɪz)
n
(Biochemistry) any of a group of proteolytic enzymes that hydrolyse peptides to amino acids

pep•ti•dase

(ˈpɛp tɪˌdeɪs, -ˌdeɪz)

n.
any of the class of enzymes that catalyze the hydrolysis of peptides or peptones to amino acids.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.peptidase - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
caspase - any of a group of proteases that mediate apoptosis
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
angiotensin converting enzyme, angiotensin-converting enzyme, ACE - proteolytic enzyme that converts angiotensin I into angiotensin II
plasminogen activator, urokinase - protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
renin - a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure
References in periodicals archive ?
According to the company, Melflufen is a lipophilic peptide-conjugated alkylator that rapidly delivers a highly cytotoxic payload into myeloma cells through peptidase activity.
Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: Meta-analysis of placebo controlled trials.
BXCL701 is an orally-available systemic innate-immune activator that inhibits dipeptidyl peptidase 8/9 and FAP developed by BTI.
Dipeptidyl peptidase 4-inhibitor (DPP4i) could prevent the inactivation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus raising plasma concentrations of the intact, active forms of these peptides and thereby improving islet function by increasing a-cell and [sz]-cell sensitivity to glucose.[1] DPP4i has been used widely for blood glucose control.
Netherton Syndrome is an autosomal recessive monogenic disease caused by mutations in the SPINK5 gene that encodes a serine peptidase inhibitor.
The company's focus is on the development of the lead product candidate Ygalo, an alkylating peptide, Peptidase Enhanced Compounds (PEnCs).
Federici et al., "Effects of dipeptidyl peptidase 4 inhibitors and sodium-glucose linked cotransporter-2 inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis," International Journal of Cardiology, vol.
[15] Gliptins or dipeptidyl peptidase (DPP)-4 inhibitors could be of some usefulness in non-diabetic individuals, as they act by increasing endogenous insulin secretion, with least hypoglycemic risk.
The team from Kolkata's CSIR-Indian Institute of Chemical Biology, Republic of Korea's Institute for Basic Science (IBS), Kolkata's Vidyasagar College and the Institute of Postgraduate Medical Education and Research (IPGMER) here has in a recent study answered a long standing question as to why diabetics have more amount of an enzyme called dipeptidyl peptidase 4 or DPP4 in their blood.
Abbreviations CAD: Coronary artery disease CRP: C-reactive protein CX3CL1: Fractalkine CX3CR1: Fractalkine receptor DPP-4: Dipeptidyl peptidase 4 IL: Interleukin LPS: Lipopolysaccharide MCP-1: Monocyte chemoattractant protein-1 PBMCs: Peripheral blood mononuclear cells T2DM: Type 2 diabetes TNF-[alpha]: Tumor necrosis factor alpha.
There is no doubt that major cardiovascular events (MACE), death, and heart failure are indeed robust clinical endpoints; however, some of the results such as the potential heart failure signal for the dipeptidyl peptidase 4 (DPP-4) inhibitor saxagliptin in SAVORTIMI 53 or the pronounced cardiovascular benefit of the sodium-dependent glucose transporter 2 (SGLT-2) inhibitors empagliflozin and canagliflozin were rather surprising.
KEY WORDS: Homarus americanus, aspartic peptidase, cysteine peptidases, crustacean protein digestion, American lobster