According to the company, Melflufen is a lipophilic peptide-conjugated alkylator that rapidly delivers a highly cytotoxic payload into myeloma cells through peptidase
Effects on lipid profile of dipeptidyl peptidase
4 inhibitors, pioglitazone, acarbose, and sulfonylureas: Meta-analysis of placebo controlled trials.
BXCL701 is an orally-available systemic innate-immune activator that inhibits dipeptidyl peptidase
8/9 and FAP developed by BTI.
4-inhibitor (DPP4i) could prevent the inactivation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus raising plasma concentrations of the intact, active forms of these peptides and thereby improving islet function by increasing a-cell and [sz]-cell sensitivity to glucose. DPP4i has been used widely for blood glucose control.
Netherton Syndrome is an autosomal recessive monogenic disease caused by mutations in the SPINK5 gene that encodes a serine peptidase
The company's focus is on the development of the lead product candidate Ygalo, an alkylating peptide, Peptidase
Enhanced Compounds (PEnCs).
Federici et al., "Effects of dipeptidyl peptidase
4 inhibitors and sodium-glucose linked cotransporter-2 inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis," International Journal of Cardiology, vol.
 Gliptins or dipeptidyl peptidase
(DPP)-4 inhibitors could be of some usefulness in non-diabetic individuals, as they act by increasing endogenous insulin secretion, with least hypoglycemic risk.
The team from Kolkata's CSIR-Indian Institute of Chemical Biology, Republic of Korea's Institute for Basic Science (IBS), Kolkata's Vidyasagar College and the Institute of Postgraduate Medical Education and Research (IPGMER) here has in a recent study answered a long standing question as to why diabetics have more amount of an enzyme called dipeptidyl peptidase
4 or DPP4 in their blood.
Abbreviations CAD: Coronary artery disease CRP: C-reactive protein CX3CL1: Fractalkine CX3CR1: Fractalkine receptor DPP-4: Dipeptidyl peptidase
4 IL: Interleukin LPS: Lipopolysaccharide MCP-1: Monocyte chemoattractant protein-1 PBMCs: Peripheral blood mononuclear cells T2DM: Type 2 diabetes TNF-[alpha]: Tumor necrosis factor alpha.
There is no doubt that major cardiovascular events (MACE), death, and heart failure are indeed robust clinical endpoints; however, some of the results such as the potential heart failure signal for the dipeptidyl peptidase
4 (DPP-4) inhibitor saxagliptin in SAVORTIMI 53 or the pronounced cardiovascular benefit of the sodium-dependent glucose transporter 2 (SGLT-2) inhibitors empagliflozin and canagliflozin were rather surprising.
KEY WORDS: Homarus americanus, aspartic peptidase
, cysteine peptidases
, crustacean protein digestion, American lobster